81054-93-5 Usage
Description
1-(2-chloroethyl)-2-nitro-1H-imidazole is a chemical compound with the molecular formula C5H6ClN3O2. It is a nitroimidazole derivative known for its potential applications in the medical field, particularly in cancer treatment and as a candidate for new therapeutic agents against infectious diseases.
Uses
Used in Cancer Treatment:
1-(2-chloroethyl)-2-nitro-1H-imidazole is used as a radiosensitizer for enhancing the effects of radiation therapy in cancer treatment. It works by inhibiting cancer cells' ability to repair DNA damage, making them more susceptible to the cytotoxic effects of radiation. This application aims to improve the efficacy of radiation therapy and potentially increase the survival rates of cancer patients.
Used in Antimicrobial Applications:
1-(2-chloroethyl)-2-nitro-1H-imidazole has been investigated for its antibacterial and antiprotozoal properties, making it a promising candidate for the development of new therapeutic agents against infectious diseases. Its potential to combat various pathogens could lead to the creation of novel treatments for a range of bacterial and protozoal infections.
Used in Pharmaceutical Research:
Due to its unique chemical structure and properties, 1-(2-chloroethyl)-2-nitro-1H-imidazole is also used in pharmaceutical research for the development of new drugs and therapies. Its potential applications in cancer treatment and infectious disease management make it an important compound for further study and development.
However, it is important to note that further research is needed to determine the safety and effectiveness of 1-(2-chloroethyl)-2-nitro-1H-imidazole in clinical applications, as its potential toxicity and side effects must be carefully evaluated.
Check Digit Verification of cas no
The CAS Registry Mumber 81054-93-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,0,5 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 81054-93:
(7*8)+(6*1)+(5*0)+(4*5)+(3*4)+(2*9)+(1*3)=115
115 % 10 = 5
So 81054-93-5 is a valid CAS Registry Number.
81054-93-5Relevant articles and documents
Radiosensitizers of hypoxic mammalian cells. 1-(hydroxyaminoalkyl)-substituted nitroimidazoles
Ahmed,Stratford,Jenkins
, p. 1763 - 1768 (2007/10/02)
A series of novel 1-(hydroxyaminoalkyl)-substituted nitroimidazoles has been synthesized as potential radiosensitizers for hypoxic mammalian cells. These compounds were synthesized via N-(hydroxyalkyl)phthalimide nitroimidazole intermediates which, on reaction with hydrazine hydrate, yielded the corresponding amines. The intermediates were prepared by reacting the epoxide derived from nitroimidazole with phthalimide and/or the epoxide derived from phthalimide with the nitroimidazole. The method was used successfully for the preparation of 2-, 4- and 5-nitroimidazole derivatives. In a modification of this procedure, 1-(2-aminoethyl)-2-nitroimidazole has been prepared by a new route which avoids the use of aziridine. These agents were tested for cytotoxicity and radiosensitizing ability in vitro using Chinese hamster V79 cells. All of the 2-nitroimidazoles tested showed toxicity similar to that previously reported for misonidazole and Ro 03-8799 (1-(2-hydroxy-3-piperidinopropyl)-2-nitroimidazole), two compounds currently undergoing clinical evaluation. In addition, all the novel primary amines were shown to function as hypoxic cell radiosensitizers. The 2-nitroimidazole derivatives were the most efficient compounds to be examined and showed at least as much activity as misonidazole.
