81068-25-9

Basic information

• Product Name: 3-[2-(dimethylamino)ethoxy]benzaldehyde
• Synonyms: 3-[2-(dimethylamino)ethoxy]benzaldehyde;benzaldehyde, 3-[2-(dimethylamino)ethoxy]-;3-[2-(dimethylamino)ethoxy]benzaldehyde(SALTDATA: FREE)
• CAS NO: 81068-25-9
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.245
• Mol File: 81068-25-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 303.081°C at 760 mmHg
• Flash Point: 137.099°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 3-[2-(dimethylamino)ethoxy]benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(dimethylamino)ethoxy]benzaldehyde(81068-25-9)
• EPA Substance Registry System: 3-[2-(dimethylamino)ethoxy]benzaldehyde(81068-25-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 81068-25-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15NO2/c1-12(2)6-7-14-11-5-3-4-10(8-11)9-13/h3-5,8-9H,6-7H2,1-2H3

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 124-40-3 dimethyl amine 
• 186191-19-5 m-(2-bromoethyloxy)benzaldehyde 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 873-62-1 m-cyanophenol 
• 500024-50-0 3-(2-(dimethylamino)ethoxy)benzonitrile 

Downstream Products

• 81813-86-7 (Z)-3-[3-(3-Dimethylamino-propoxy)-phenyl]-2-(1H-indol-3-yl)-acrylonitrile; hydrochloride 
• 86759-07-1 [4-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-yl)-piperazin-1-yl]-[1-[3-(2-dimethylamino-ethoxy)-phenyl]-meth-(E)-ylidene]-amine 
• 217964-98-2 bis(2,5-dimethyl-4-hydroxyphenyl)[3-(2-dimethylamino-1-ethoxy)phenyl]methane 
• 1034251-38-1 N-[3-(2-dimethylaminoethoxy)benzylidene]-N',N'-dimethylethane-1,2-diamine 
• 1034251-39-2 N-[3-(2-dimethylaminoethoxy)benzylidene]-N',N'-dimethylpropane-1,3-diamine 
• 1172118-30-7 2-[3-(2-dimethylaminoethoxy)phenyl]-4,5-diphenylimidazole 
• 1155224-38-6 6-amino-5-[{3-(2-dimethylaminoethoxy)benzylidene}amino]-1,3-dimethyluracil 
• 1301626-04-9 C₁₇H₂₉N₃O 
• 1402709-71-0 2-(3-(6-chloro-7-(4-((5-methylisoxazol-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy)-N,N-dimethylethanamine 

Relevant articles and documents

4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS

New pyrazolopyridmiin-2-yl derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).