81128-29-2

Basic information

• Product Name: Cyclohexyl-(2-methyl-pyridin-4-yl)-methanone
• Synonyms: Cyclohexyl-(2-methyl-pyridin-4-yl)-methanone
• CAS NO: 81128-29-2
• Molecular Weight: 203.284
• Mol File: 81128-29-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexyl-(2-methyl-pyridin-4-yl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexyl-(2-methyl-pyridin-4-yl)-methanone(81128-29-2)
• EPA Substance Registry System: Cyclohexyl-(2-methyl-pyridin-4-yl)-methanone(81128-29-2)

Safety Data

• Hazardous Substances Data: 81128-29-2(Hazardous Substances Data)

Upstream product

• 22282-99-1 4-bromo-2-methylpyridine 
• 1115492-92-6 2-methyl-4-pyridylzinc bromide 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 79534-90-0 2-methyl-4-(trimethylstannyl)pyridine 

Relevant articles and documents

Preparation 2-substituted-4-pyridylzinc bromides via direct insertion of active zinc and their coupling reactions

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Studies on Organometallic Compounds. III. Reaction of Trimethylstannylazines with Acyl Chlorides. A Novel C-C Bond Formation of Pyridine Nuclei

Introduction of an acyl group at the α-, β-, and γ-positions of pyridine nuclei was accomplished. 2-Trimethylstannyl-pyridine and -quinoline and 1-trimethylstannylisoquinoline directly reacted with various acyl chlorides to give the corresponding 2-pyridyl, 2-quinolyl, and 1-isoquinolyl ketones, respectively.Reaction of 3-trimethylstannylpyridine, -quinoline, and -isoquinoline with acyl chlorides proceeded smoothly under catalysis by PdCl2 or PdCl2(PPh3)2 to afford the corresponding ketones in good yields.Similary, 4-pyridyl, -quinolyl, and -isoquinolyl ketones were prepared from corresponding 4-trimethylstannyl derivatives and acyl chlorides.Keywords--trimethylstannylazine; palladium-catalyzed reaction; acylation; palladium dichloride; dichlorobis(triphenylphosphine)palladium(II)