81168-94-7

Basic information

• Product Name: BENZENEACETIC ACID, A-HYDROXY-A-METHYL-4-NITRO-
• Synonyms: BENZENEACETIC ACID, A-HYDROXY-A-METHYL-4-NITRO-
• CAS NO: 81168-94-7
• Molecular Formula: C₉H₉NO₅
• Mol File: 81168-94-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZENEACETIC ACID, A-HYDROXY-A-METHYL-4-NITRO-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEACETIC ACID, A-HYDROXY-A-METHYL-4-NITRO-(81168-94-7)
• EPA Substance Registry System: BENZENEACETIC ACID, A-HYDROXY-A-METHYL-4-NITRO-(81168-94-7)

Safety Data

• Hazardous Substances Data: 81168-94-7(Hazardous Substances Data)

Upstream product

• 69813-77-0 2-(4-nitro-phenyl)-2-hydroxypropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 124-38-9 carbon dioxide 
• 1469462-85-8 1-cyano-1-(4-nitrophenyl)ethyl diethyl phosphate 

Downstream Products

• 131894-65-0 2-Hydroxy-N-methyl-2-(4-nitrophenyl)propiohydroxamsaeure 
• 81168-91-4 2-acetoxy-2-(4-nitrophenyl)propionic acid 
• 131894-64-9 4,6-Dimethyl-6-(4-nitrophenyl)-1,3,2,4-dioxathiazinan-5-on-2-oxid 
• 131131-34-5 ZM 147376 

Relevant articles and documents

Synthesis of α-hydroxycarboxylic acids from various aldehydes and ketones by direct electrocarboxylation: A facile, efficient and atom economy protocol

In present work, the formation of α-hydroxycarboxylic acids have been described from various aromatic aldehydes and ketones via direct electrocarboxylation method with 80-92% of yield without any side product and can be purified by simple recrystallization using sacrificial Mg anode and Pt cathode in an undivided cell, CO2at (1 atm) was continuously bubbled in the cell throughout the reaction using tetrapropylammonium chloride as a supporting electrolyte in acetonitrile. The synthesized compounds obtained in fair to excellent yield with a high level of purity. The characterization of electrocarboxylated compounds was done with spectroscopic techniques like IR, NMR (1H & 13C), mass and elemental analysis.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Electrochemical synthesis of α-hydroxycarboxylic acids from acetophenones

α-Hydroxy carboxylic acids are synthesized in 80-86% isolated yields by electrochemical carboxylation of methyl aryl ketones in the presence of carbon dioxide (1 atm.) using a platinum cathode and a sacrificial magnesium anode at a constant current density of 10 mA/cm2. Reversibility of the carbonyl group reduction and generation of anionic radical were shown by cyclic voltammetry. Copyright Taylor & Francis LLC.