81186-33-6

Basic information

• Product Name: E-MALEIMIDOCAPRONIC ACID HYDRAZIDE
• Synonyms: E-MALEIMIDOCAPRONIC ACID HYDRAZIDE;1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, hydrazide;ε-MaleiMidocaproic acid hydrazide;N-(ε-MaleiMidocaproic acid)hydrazide(EMCH);6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide;6-(2,5-Dioxopyrrol-1-yl)hexanehydrazide
• CAS NO: 81186-33-6
• Molecular Formula: C₁₀H₁₅N₃O₃
• Molecular Weight: 225.24
• Mol File: 81186-33-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: E-MALEIMIDOCAPRONIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: E-MALEIMIDOCAPRONIC ACID HYDRAZIDE(81186-33-6)
• EPA Substance Registry System: E-MALEIMIDOCAPRONIC ACID HYDRAZIDE(81186-33-6)

Safety Data

• Hazardous Substances Data: 81186-33-6(Hazardous Substances Data)

Usage

Uses

for preparation of acrylic derivatives, e.g., of dyes or biological substrates

Upstream product

• 55750-63-5 6-maleimidohexanoic acid N-hydroxylsuccinimide ester 

Downstream Products

• 151038-96-9 doxorubicin(6-maleimidocaproyl)hydrazone 
• 76-05-1 trifluoroacetic acid 
• 116919-18-7 N-biotinoyl-N′-(6-maleimidohexanoyl)hydrazide 

Relevant articles and documents

Method for preparing biotin maleimide

The invention discloses a method for preparing biotin maleimide. The method comprises the following steps of: 1, reacting 6-maleimidohexanoic acid compound (1) with N-hydroxysuccinimide under the action of a condensing agent to obtain a 6-maleimidohexanoic acid N-hydroxysuccinimide ester compound (2); 2, treating the 6-maleimidohexanoic acid N-hydroxysuccinimide ester compound (2) by using hydrazine hydrate to obtain a 6- maleimidocaproyl hydrazide compound (3); 3, reacting a biotin compound (4) with an acyl halide reagent to obtain a biotinyl acyl halide compound (5); and 4, reacting the 6-maleimidocaproyl hydrazide compound (3) with the biotinyl acyl halide compound (5) to obtain a biotin maleimide compound (6). The method for preparing the biotin maleimide, disclosed by the invention, has the beneficial effects of being suitable for scale-up production, easily available in raw materials, simple in preparation process and friendly to environment.