812-00-0Relevant articles and documents
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Bothner-By,A.A.,Trautwein,W.-P.
, p. 2189 - 2192 (1971)
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Loci of ceric cation mediated hydrolyses of dimethyl phosphate and methyl methylphosphonate
Moss, Robert A.,Morales-Rojas, Hugo
, p. 1791 - 1793 (1999)
(formula presented) Dimethyl phosphate and methyl methylphosphonate are cleaved by Ce(IV)-mediated hydrolysis with 91% and 88% P-O scission, respectively, and rate accelerations of ≥ 1010 relative to pH 7 P-O hydrolysis.
METHOD FOR PRODUCING PHOSPHOESTER COMPOUND
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Paragraph 0023; 0026-0028, (2021/09/27)
PROBLEM TO BE SOLVED: To provide a method whereby, a phosphate compound selected from the group consisting of orthophosphoric acid, phosphonic acid, phosphinic acid, and anhydrides of them is used as raw material and, by one stage reaction, a corresponding phosphoester compound is produced. SOLUTION: To an aqueous solution of a phosphate compound, added is an organic silane or siloxane compound having an alkoxy group or an aryloxy group, and the mixture is subjected to a heating reaction, thereby producing a corresponding phosphoester compound without requiring a catalyst. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
An Unusual Two-Step Hydrolysis of Nerve Agents by a Nanozyme
Khulbe, Kritika,Roy, Punarbasu,Radhakrishnan, Anusree,Mugesh, Govindasamy
, p. 4840 - 4845 (2018/09/27)
Organophosphate-based nerve agents irreversibly inhibit acetylcholinesterase enzyme, leading to respiratory failure, paralysis and death. Several organophosphorus hydrolases are capable of degrading nerve agents including pesticides and insecticides. Development of stable artificial enzymes capable of hydrolysing nerve agents is important for the degradation of environmentally toxic organophosphates. Herein, we describe a Zr-incorporated CeO2 nanocatalyst that can be used for an efficient capture and hydrolysis of nerve agents such as methyl paraoxon to less toxic monoesters. This unusual sequential degradation pathway involves a covalently linked nanocatalyst-phosphodiester intermediate.
Intriguing structural chemistry of neutral and anionic layered monoalkylphosphates: Single-source precursors for high-yield ceramic phosphates
Bhat, Gulzar A.,Kalita, Alok Ch.,Murugavel, Ramaswamy
, p. 5390 - 5401 (2017/09/26)
Building up on an available synthetic methodology, phosphate monoesters ROPO3H2 have been synthesized in good yields. The synthetic procedure employed features acetic anhydride mediated activation of phosphoric acid in the presence of alcohols, leading to the formation of phosphate monoesters. The products have been isolated as their cyclohexyl amine salts, [CyNH3]2[(MeO)PO3]·3H2O (1) and [CyNH3][(RO)PO3H] (Cy = cyclohexyl; R = Et (2), iPr (3), or tBu (4)). Neutralization of 1-4 by readily available inexpensive ion exchange resin Amberlite produces monoalkylphosphates (RO)P(O)(OH)2 (R = Me (5), Et (6), iPr (7), or tBu (8)). Thermally labile 1-4 and 7 have been structurally characterized by single crystal X-ray diffraction studies. Due to their intrinsic thermal instability due to β-H elimination, these compounds can be used as ligands for the preparation of single-source precursors for ceramic phosphates by reacting them with suitable metals ions. It is also possible to isolate co-crystals of the anionic and neutral forms of these phosphates as it has been demonstrated in the isolation and structural characterization of [(iPrO)PO3H2]·{[CyNH3][(iPrO)PO3H]} (9). To demonstrate the utility of these monoalkylphosphates in the low-temperature synthesis of metal phosphate bioceramics, isopropyl phosphate 7 has been employed to prepare calcium phosphate [{Ca((iPrO)PO3)(OH2)}·H2O]n (10), which undergoes neat thermal decomposition in two stages to lose water and propene to yield β-Ca2P2O7 at low temperatures (280 °C).
