81202-06-4

Basic information

• Product Name: L-PROLINE (1-13C)
• Synonyms: L-PROLINE (1-13C);L-PROLINE-1-13C, 99 ATOM % 13C
• CAS NO: 81202-06-4
• Molecular Formula: C5H9NO2
• Molecular Weight: 116.14
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids;Metabolic Research;Stable Isotopes;Alphabetical Listings;P
• Mol File: 81202-06-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 228 °C (dec.)(lit.)
• Appearance: /
• CAS DataBase Reference: L-PROLINE (1-13C)(CAS DataBase Reference)
• NIST Chemistry Reference: L-PROLINE (1-13C)(81202-06-4)
• EPA Substance Registry System: L-PROLINE (1-13C)(81202-06-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 81202-06-4(Hazardous Substances Data)

Upstream product

• 108395-12-6 1,2,3,4,5-⁽¹³⁾C₅,⁽¹⁵⁾N-L-glutamic acid 
• 1196980-37-6 C₁₇⁽¹³⁾C₂H₁₉NO₂ 
• 14742-26-8 [¹³C]methanol 

Relevant articles and documents

Stereoselective synthesis of stable isotope-labeled L-α-amino acids: Enantioselective synthesis of 13C-, 15N-labeled L-proline using Oppolzer's glycine template

We have developed a stereoselective route to the synthesis of stable isotope-labeled L-proline. Alkylation of (2R)-N-{N'-[bis(methylthio)methylidine]glycyl}bornane-10,2-sultam with 3-chloro-iodopropane yielded (2R)-N-{(2'S)-2'-{[Bis(methylthio)methylidine]amino}5-chloropentan-1 -oyl}bornane-10,2-sultam. Cyclization to the imino acid occurred during the sequential removal of the α-amino protecting group and the chiral auxiliary.

Enantioselective syntheses of α-Fmoc-Pbf-[2-13C]-L- arginine and Fmoc-[1,3-13C2]-L-proline and incorporation into the neurotensin receptor 1 ligand, NT8-13

(Chemical Equation Presented) Enantioselective syntheses of selectively labeled, orthogonally protected [2-13C]-L-arginine and [1,3- 13C2]-L-proline are described from the commercially available precursors [2-13C]bromoacetic acid and potassium [ 13C]cyanide. Interestingly the enhanced signal assigned to C-2 in the 13C NMR spectrum of α-Fmoc-Pbf-[2-13C]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-13C]-Arg9 and [1,3-13C2]-Pro10 labeled ligand (NT8-13) by manual Fmoc-SPSS.