81202-41-7

Basic information

• Product Name: Leucine, 3-hydroxy-, methyl ester (9CI)
• Synonyms: Leucine, 3-hydroxy-, methyl ester (9CI)
• CAS NO: 81202-41-7
• Molecular Formula: C7H15NO3
• Molecular Weight: 0
• Mol File: 81202-41-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Leucine, 3-hydroxy-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Leucine, 3-hydroxy-, methyl ester (9CI)(81202-41-7)
• EPA Substance Registry System: Leucine, 3-hydroxy-, methyl ester (9CI)(81202-41-7)

Safety Data

• Hazardous Substances Data: 81202-41-7(Hazardous Substances Data)

Usage

General Description

Leucine, 3-hydroxy-, methyl ester (9CI) is a chemical compound that is a derivative of the amino acid leucine. It is a methyl ester, meaning that it has a methyl group attached to the carboxyl group of the amino acid. Leucine, 3-hydroxy-, methyl ester (9CI) is commonly used as a flavoring agent and fragrance ingredient in the food and cosmetic industries. It is also used in organic synthesis as a building block for the production of other compounds. However, there is limited information available on the specific properties and uses of this chemical, so further research may be needed to fully understand its potential applications.

Relevant articles and documents

Diastereo- and enantioselective hydrogenation of α-amino-β-keto ester hydrochlorides catalyzed by an iridium complex with MeO-BIPHEP and NaBArF: Catalytic cycle and five-membered chelation mechanism of asymmetric hydrogenation

The development of Ir-catalyzed asymmetric hydrogenation of α-amino-β-keto ester hydrochlorides is described. This reaction proceeds through a dynamic kinetic resolution to produce anti-β-hydroxy- α-amino acid esters in a high diastereo- and enantioselective manner. Mechanistic studies have revealed that this unique asymmetric hydrogenation proceeds through reduction of the ketone moiety via the five-membered transition state involving the chelation between the oxygen of the ketone and the nitrogen of the amine function. The relationship studies between the hydrogen pressure and the stereoselectivity have disclosed two mechanisms dependent on hydrogen pressure. Under low hydrogen pressure (15 atm), the reaction rate proportionally increased with the hydrogen pressure. However, under the high hydrogen conditions, the reaction rate exponentially accelerated along with the increasing hydrogen pressure, which suggests the participation of two or more of hydrogen atoms. Apply some pressure: The Ir-catalyzed asymmetric hydrogenation of α-amino-β-keto ester hydrochlorides proceeds through a dynamic kinetic resolution to produce anti-β-hydroxy-α-amino acid esters in a high diastereo- and enantioselective manner (see scheme). Mechanistic studies revealed that this unique asymmetric hydrogenation proceeds through reduction of the ketone moiety via the five-membered transition state.