81227-99-8

Basic information

• Product Name: 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE
• Synonyms: 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE;4'-(BENZYLOXY)-3'-FLUOROACETOPHENONE;1-(4-Benzyloxy-3-fluoro-phenyl)-ethanone
• CAS NO: 81227-99-8
• Molecular Formula: C₁₅H₁₃FO₂
• Molecular Weight: 244.26
• Mol File: 81227-99-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 82-85
• Boiling Point: 383.3°C at 760 mmHg
• Flash Point: 179.3°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 4.44E-06mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE(81227-99-8)
• EPA Substance Registry System: 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE(81227-99-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 81227-99-8(Hazardous Substances Data)

Usage

General Description

1-[4-(Benzyloxy)-3-fluorophenyl]-1-ethanone is a chemical compound with the molecular formula C16H15FO2. It is an aromatic ketone that contains a benzyl ether and a fluorine-substituted phenyl group. 1-[4-(BENZYLOXY)-3-FLUOROPHENYL]-1-ETHANONE is commonly used in organic synthesis and pharmaceutical research, and it has potential applications in drug development and medicinal chemistry. Its unique structural features make it a valuable building block for the synthesis of various biologically active compounds. Additionally, its benzyloxy and fluorine substituents may impart specific pharmacological properties, making it a potentially useful molecular scaffold for the development of new drugs.

InChI:InChI=1/C15H13FO2/c1-11(17)13-7-8-15(14(16)9-13)18-10-12-5-3-2-4-6-12/h2-9H,10H2,1H3

Upstream product

• 403-14-5 3-fluoro-4-hydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 2105-94-4 4-bromo-2-fluorophenol 
• 367-12-4 2-fluorophenol 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 133057-82-6 1-benzyloxy-4-bromo-2-fluorobenzene 

Downstream Products

• 177782-02-4 Acetic acid 4-benzyloxy-3-fluoro-phenyl ester 
• 73898-27-8 1-(4-benzyloxy-3-fluorophenyl)-2-bromoethanone 
• 73898-42-7 4-(2-Amino-1-hydroxy-ethyl)-2-fluoro-phenol; hydrochloride 
• 1071167-55-9 2-(4-(benzyloxy)-3-fluorophenyl)-2-methyl-1,3-dioxolane 
• 1290181-30-4 methyl 3-(4-(benzyloxy)-3-fluorophenyl)-3-oxopropanoate 
• 1042702-48-6 2-(4-benzyloxy-3-fluorophenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1042702-50-0 4-(2-(3-fluoro-4-hydroxyphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1292298-83-9 4-(2-(4-hydroxy-3-nitrophenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 

Relevant articles and documents

Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

PESTICIDAL SUBSTITUTED PHENYLETHERS

The invention relates to the use of phenylether derivatives of formula (I), to compositions thereof for the control of pests, including arthropods and helminths.

β1-Selective Adrenoceptor Antagonists. 2. 4-Ether-Linked Phenoxypropanolamines

A series of 4-substituted phenoxypropanolamines was prepared and examined for β-adrenoceptor activity.Some of the compounds, especially the oxy>ethoxy>phenoxy>propanolamines (14, 15, and 24), showed potent β1-blo