812637-24-4

Basic information

• Product Name: Pyridine, 2-methyl-5-[(2-phenylethyl)thio]- (9CI)
• Synonyms: Pyridine, 2-methyl-5-[(2-phenylethyl)thio]- (9CI)
• CAS NO: 812637-24-4
• Molecular Formula: C14H15NS
• Molecular Weight: 229.3406
• Product Categories: METHYL
• Mol File: 812637-24-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 2-methyl-5-[(2-phenylethyl)thio]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-methyl-5-[(2-phenylethyl)thio]- (9CI)(812637-24-4)
• EPA Substance Registry System: Pyridine, 2-methyl-5-[(2-phenylethyl)thio]- (9CI)(812637-24-4)

Safety Data

• Hazardous Substances Data: 812637-24-4(Hazardous Substances Data)

Upstream product

• 3430-13-5 5-bromo-2-methylpyridine 
• 4410-99-5 2-mercaptophenylethane 

Relevant articles and documents

METHOD FOR PRODUCING THIOETHER COMPOUND

Disclosed is an efficient and widely-applicable method for commercially producing a thioether compound or a thiol compound which is useful as a pharmaceutical compound or a production intermediate of it. Specifically disclosed is a method for producing a thioether compound represented by the general formula [I] below or a salt thereof. This method is characterized in that a compound represented by the following general formula [III]: [III] (wherein X represents a bromine atom, a chlorine atom or a trifluoromethylsulfonyloxy group, and ring A represents an aryl group or a heteroaryl ring group) or a salt thereof is reacted with a thiol compound represented by the following general formula [II]: [II] or a salt thereof in the presence of a palladium compound such as Pd2(dba)3, a base such as i-Pr2NEt and a phosphorus compound represented by the following formula [AA].

A general palladium-catalyzed coupling of aryl bromides/triflates and thiols

(Chemical equation presented) We have developed an efficient palladium-catalyzed carbon-sulfur bond formation reaction of aryl bromides, triflates, and activated aryl chloride. Using this protocol, we have shown tolerance to a wide variety of aryl thiols and alkyl thiols that can also be used as sulfide equivalents.