812666-67-4

Basic information

• Product Name: 2-cyanomethyl-5-[4-(piperidin-1-yl)benzylidenyl]-4,5-dihydro-4-thiazolinone
• CAS NO: 812666-67-4
• Molecular Weight: 311.407
• Mol File: 812666-67-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyanomethyl-5-[4-(piperidin-1-yl)benzylidenyl]-4,5-dihydro-4-thiazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyanomethyl-5-[4-(piperidin-1-yl)benzylidenyl]-4,5-dihydro-4-thiazolinone(812666-67-4)
• EPA Substance Registry System: 2-cyanomethyl-5-[4-(piperidin-1-yl)benzylidenyl]-4,5-dihydro-4-thiazolinone(812666-67-4)

Safety Data

• Hazardous Substances Data: 812666-67-4(Hazardous Substances Data)

Upstream product

• 10338-57-5 4-(piperidin-1-yl)benzaldehyde 
• 74246-64-3 2-cyanomethyl-2-thiazolin-4-one 

Relevant articles and documents

Studies on thiazolopyridines. Part 5: Synthesis of hitherto unknown thiazolinone and thiazolo[3,2-a]pyridine derivatives having in their structure the morpholin-4-yl moiety

Condensation of thiazolinone 1 with, benzaldehydes 2a,b in ethanolic piperidine afforded the methylidene derivatives 3a,b. Cyclocondensation of compound 3b with malononitrile furnished the novel thiazolo[3,2-a]-pyridine 5. Also, compound 3b was condensed with dimethylformamide-dimethylacetal (DMF-DMA) and triethylorthoformate to yield N,N-dimethylamino 6 and ethoxymethylene 7 derivatives respectively. The novel thiazolo[3,2-a]pyridines 10a,b were obtained by cyclocondensation of compounds 3a,b with benzylidenemalononitriles 8a,b. Similarly, cyclocondensation of compound 3b with benzylidenemalononitrile 11 afforded the thiazolopyridines 12a-c. Ternary condensation of compound (12), 4-morpholinobenzaldehyde 2b and malononitrile (1:1:1 molar ratio) produced, the thiazolopyridines 14a-c. When compound 10b was subjected to react with malononitrile in dioxane/piperidine under reflux the novel condensed heterocyclic system 18 was obtained. Treatment of ortho-aminocarbonitrile 10b with formic acid, aromatic aldehyde and triethylorthoformate furnished the thiazolo[2′,3′:1,6]pyrido[2,3-d] pyrimidine 20, azomethine 21a,b and ethoxymethylene 22 derivatives respectively. The structure of the synthesized compounds was established by analytical and spectral data.