81308-22-7

Basic information

• Product Name: N-(4-Isopropylbenzyl)aniline
• Synonyms: N-(4-Isopropylbenzyl)aniline
• CAS NO: 81308-22-7
• Molecular Formula: C₁₆H₁₉N
• Molecular Weight: 225.33
• Mol File: 81308-22-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-Isopropylbenzyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Isopropylbenzyl)aniline(81308-22-7)
• EPA Substance Registry System: N-(4-Isopropylbenzyl)aniline(81308-22-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 81308-22-7(Hazardous Substances Data)

Upstream product

• 17693-88-8 N-(4-isopropylbenzylidene)benzenamine 
• 10407-16-6 1-(4-isopropylbenzylidene)-2-phenylhydrazine 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 62-53-3 aniline 
• 536-60-7 cuminol 
• 98-95-3 nitrobenzene 
• 122-03-2 (4-isopropylbenzaldehyde) 
• 99081-88-6 N-4-Isopropylphenylmethylene benzenamine N-oxide 

Relevant articles and documents

Enhanced Hydride Donation Achieved Molybdenum Catalyzed Direct N-Alkylation of Anilines or Nitroarenes with Alcohols: From Computational Design to Experiment

An example of homogeneous Mo-catalyzed direct N-alkylation of anilines or nitroarenes with alcohols is presented. The DFT aimed design suggested the easily accessible bis-NHC-Mo(0) complex features a strong hydride-donating ability, achieving effective N-alkylation of anilines or challenging nitroarenes with alcohols. The enhanced hydride-donating strategy should be useful in designing highly active systems for borrowing hydrogen transformations.

Convenient and Reusable Manganese-Based Nanocatalyst for Amination of Alcohols

The development of new sustainable nanocatalytic systems for green chemical synthesis is a growing area in chemical science. Herein, a reusable heterogeneous N-doped graphene-based manganese nanocatalyst (Mn@NrGO) for selective N-alkylation of amines with alcohols is described. Mechanistic studies illustrate that the catalytic reaction follows a domino dehydrogenation-condensation-hydrogenation sequence of alcohols and amines with the formation of water as the sole by-product. The scope of the reaction is extended to the synthesis of pharmaceutically important N-alkylated amine intermediates. The heterogeneous nature of the catalyst made it easy to separate for long-term performance, and the recycling study revealed that the catalyst was robust and retained its activity after several recycling experiments.

Direct electrochemical reductive amination between aldehydes and amines with a H/D-donor solvent

A novel electrochemical synthesis protocol has been achieved for reductive amination between aldehydes and amines in undivided cells at room temperature. Under metal-free and external-reductant-free electrolysis conditions, various important secondary amine products are obtained in moderate-to-high yields. Deuterium-labeling experiments have demonstrated that low-toxicity DMSO acts both as a solvent and a H-donor in the reaction. On this basis, various deuterium-labeled products with good-to-excellent D-incorporation have been synthesized by using DMSO-d6 as a solvent. Furthermore, a molecule with GR-antagonistic activity has been synthesized through further sulfonylation.