81346-72-7Relevant articles and documents
Studies on the metabolism of atenolol. Characterization and determination of a new urinary metabolite in the rat
Matsuki,Ito,Komatsu,Nambara
, p. 196 - 201 (2007/10/02)
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81346-72-7
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Basic information
- Product Name: (2H6)-atenolol
- Synonyms:
- CAS NO:81346-72-7
- Molecular Formula:
- Molecular Weight: 272.293
- EINECS: N/A
- Product Categories: N/A
- Mol File: 81346-72-7.mol
- Article Data: 1
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (2H6)-atenolol(CAS DataBase Reference)
- NIST Chemistry Reference: (2H6)-atenolol(81346-72-7)
- EPA Substance Registry System: (2H6)-atenolol(81346-72-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 81346-72-7(Hazardous Substances Data)
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81346-72-7 Usage
Description
(2H6)-atenolol is a stable isotope-labeled form of atenolol, a commonly prescribed beta-blocker medication. It incorporates deuterium atoms, which enable the tracking and monitoring of the drug's pharmacokinetics, including absorption, distribution, metabolism, and excretion, using advanced analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.Uses
Used in Pharmaceutical Research:(2H6)-atenolol is used as a research tool for enhancing the understanding of atenolol's behavior within the body. Its application aids in pharmacokinetic studies and drug development research, providing valuable insights into the drug's efficacy, safety, and optimal dosing regimens.
Used in Drug Metabolism and Pharmacokinetics Studies:
In the field of drug metabolism and pharmacokinetics, (2H6)-atenolol serves as a labeled compound to monitor the drug's metabolic pathways and clearance rates. This information is crucial for assessing how the body processes the medication and for improving the drug's therapeutic profile.
Used in Clinical Trials:
(2H6)-atenolol is utilized in clinical trials to compare the pharmacokinetic properties of atenolol with other formulations or treatments. This helps in evaluating the bioequivalence or superiority of new drug formulations and contributes to the optimization of treatment strategies for cardiovascular conditions.
Used in Mass Spectrometry and NMR Analysis:
In analytical chemistry, (2H6)-atenolol is employed as an internal standard or a reference compound in mass spectrometry and NMR analysis. Its distinct isotopic signature allows for accurate quantification and identification of atenolol and its metabolites in biological samples, ensuring the reliability of experimental results.
Check Digit Verification of cas no
The CAS Registry Mumber 81346-72-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,3,4 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.Calculate Digit Verification of CAS Registry Number 81346-72:
(7*8)+(6*1)+(5*3)+(4*4)+(3*6)+(2*7)+(1*2)=127
127 % 10 = 7
So 81346-72-7 is a valid CAS Registry Number.
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81346-72-7Downstream Products
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(2H6)-atenolol
