81347-68-4Relevant articles and documents
Dual Cobalt and Photoredox Catalysis Enabled Intermolecular Oxidative Hydrofunctionalization
Sun, Han-Li,Wang, Jun-Jie,Yang, Fan,Ye, Wei-Ting,Zhu, Rong
, p. 4983 - 4989 (2020/05/27)
A general protocol has been developed for the Markovnikov-selective intermolecular hydrofunctionalization based on visible-light-mediated Co/Ru dual catalysis. The key feature involves the photochemical oxidation of an organocobalt(III) intermediate deriv
MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS
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Page/Page column 147-148, (2010/10/20)
Disclosed are agents having pharmacological activity against cellular receptors and intracellular singaling, particularly receptors and sigaling pathways of central nervous system (CNS) neurotransmitters. Also disclosed are related methods and compositions for the treatment or prevention of diseases or disorders using the agents.
Identification and comparison of impurities in fluoxetine hydrochloride synthesized by seven different routes
Wirth, David D.,Miller, Marybeth S.,Boini, Sathish K.,Koenig, Thomas M.
, p. 513 - 519 (2013/08/07)
Fluoxetine HCl was prepared by seven different synthetic routes, all previously reported. The major impurities in each route were identified by GC/MS, HPLCMS, and gradient HPLC analysis. Impurities were classified as being derived from impurities in 4-chlorobenzotrifluoride, those arising during the SNAr reaction of this compound and 3-methylamino-1-phenyl-propanol, and those arising during the synthesis of this alcohol. Fifteen impurities belonging to the latter two categories were identified, and their structures were confirmed by synthesis of authentic material for most of the compounds. It was found that a variety of analytical tools was needed for complete characterization of the impurity profile of fluoxetine HCl and that purification of the intermediate and recrystallization of the drug itself are highly effective in minimizing the levels of the impurities.