81423-83-8

Basic information

• Product Name: ethyl 4-propylbenzoate
• Synonyms: ethyl 4-propylbenzoate;4-Propylbenzoic acid ethyl ester
• CAS NO: 81423-83-8
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25424
• Mol File: 81423-83-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 4-propylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-propylbenzoate(81423-83-8)
• EPA Substance Registry System: ethyl 4-propylbenzoate(81423-83-8)

Safety Data

• Hazardous Substances Data: 81423-83-8(Hazardous Substances Data)

Upstream product

• 2438-05-3 4-n-propylbenzoic acid 
• 81423-72-5 (2E,4E)-2-(2-Methanesulfinyl-2-methylsulfanyl-ethyl)-octa-2,4-dienoic acid ethyl ester 
• 125261-30-5 p-(ethoxycarbonyl)phenyl triflate 
• 75-26-3 isopropyl bromide 
• 7335-27-5 ethyl 4-chlorobenzoate 

Relevant articles and documents

Efficient Pd-Catalyzed Direct Coupling of Aryl Chlorides with Alkyllithium Reagents

Organolithium compounds are amongst the most important organometallic reagents and frequently used in difficult metallation reactions. However, their direct use in the formation of C?C bonds is less established. Although remarkable advances in the coupling of aryllithium compounds have been achieved, Csp2?Csp3 coupling reactions are very limited. Herein, we report the first general protocol for the coupling or aryl chlorides with alkyllithium reagents. Palladium catalysts based on ylide-substituted phosphines (YPhos) were found to be excellently suited for this transformation giving high selectivities at room temperature with a variety of aryl chlorides without the need for an additional transmetallation reagent. This is demonstrated in gram-scale synthesis including building blocks for materials chemistry and pharmaceutical industry. Furthermore, the direct coupling of aryllithiums as well as Grignard reagents with aryl chlorides was also easily accomplished at room temperature.

Reactions of Vinylphosphonates. 2. Synthesis of Functionalized Dienes, Trienes, and Their Analogues. Synthetic Aplications to Regioselectively Functionalized Benzene Derivatives

The phosphoryl-stabilized carboanions prepared from vinylphosphonates 1a,b and various carbanions 2a-c react with aldehydes 3 to give olefins having various functional groups.The dienes 5c-g produced by the reaction using α,β-unsaturated aldehydes and a methyl (methylsulfinyl)methyl sulfide carbanion (2b) easily undergo thermolysis to afford reactive intermediate 1-methylthio 1,3,5-trienes, which are converted into the 1,4-disubstituted benzenes 7a-e in 27-56percent overall isolated yields via the electrocyclic reaction into cyclohexadienes and subsequent elimination of methanethiol.Thermolysis of the reaction product using ethyl α-(diethylphosphono)acrylate (1a), 2b, and 1,4-bis(2-formylethenyl)benzene (3g) produces 4,4''-bis(ethoxycarbonyl)-1,1':4',1''-terphenyl (7f) in 16percent yield.The reaction using an ethyl (methylthio)acetate carbanion (2c) instead of 2b gives thermally stable dienes 5i-l in 38-52percent yields.Oxidation of the dienes 5i,k,l followed by thermolysis, leads to the 1,2,4-trisubstituted (8a,b) and 1,2-disubstituted benzenes (9).Similar treatment of the product 5m derived from 1a, 2c, and 3-phenylpropargylaldehyde (3f) produces a mixture of 2,4-bis(ethoxycarbonyl)biphenyl (8a) and ethyl 4-(ethoxycarbonyl)-7-phenylhepta-2,4-dien-6-ynoate (11) in 23percent and 32percent yields.