81438-52-0

Basic information

• Product Name: 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE)
• Synonyms: 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE);3-Carboxy-2,6-dimethylimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine-3-carboxylic acid, 2,6-dimethyl-
• CAS NO: 81438-52-0
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.1986
• Mol File: 81438-52-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE)(81438-52-0)
• EPA Substance Registry System: 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE)(81438-52-0)

Safety Data

• Hazardous Substances Data: 81438-52-0(Hazardous Substances Data)

Usage

General Description

2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid, also known as SALTDATA: FREE, is a chemical compound with potential use in pharmaceuticals. It belongs to the class of imidazo[1,2-a]pyridines and contains a carboxylic acid functional group. 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylic acid(SALTDATA: FREE) has been studied for its potential biological activities, including its role as an anticancer agent and its ability to inhibit DNA adduct formation. It is also being researched for its potential use in the treatment of inflammatory bowel disease. However, further research is needed to fully understand its pharmacological properties and potential applications.

Upstream product

• 81438-51-9 ethyl 2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Relevant articles and documents

N-(2-Phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides containing various amine moieties: Design, synthesis and antitubercular activity

Seven 2,6-disubstituted N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamide series containing various amine moieties were designed and synthesized as new anti-TB agents. Many of them show excellent in vitro activity against both drug-sensitive MTB strain H37Rv and two MDR-MTB clinical isolates (MIC: 0.002–0.030 μg/mL). Compounds 2f, 5e and 5g display acceptable safety and pharmacokinetic profiles, opening a new direction for further development.

Design, synthesis and biological activity of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides as new antitubercular agents

A series of N-(2-phenoxy)ethyl imidazo[1,2-a]pyridine-3-carboxamides (IPAs), based on the structure of WZY02 discovered in our lab, were designed and synthesized as new anti-TB agents. Results reveal that many of them exhibit excellent in vitro inhibitory activity with low nanomolar MIC values against both drug-sensitive MTB strain H37Rv and drug-resistant clinical isolates. Compounds 15b and 15d display good safety and pharmacokinetic profiles, suggesting their promising potential to be lead compounds for future antitubercular drug discovery.

Design, synthesis and antimycobacterial activity of novel imidazo[1,2-a]pyridine-3-carboxamide derivatives

We report herein the design and synthesis of “novel imidazo [1,2-a]pyridine-3-carboxamides (IPAs)” bearing a variety of different linkers, based on the structure of IMB-1402 discovered in our lab. Results reveal that 2,6-dimethyl-N-[2-(phenylamino)ethyl] IPAs with an electron-donating group on the benzene ring as a potent scaffold. Compounds 26g and 26h have considerable activity (MIC: 0.041–2.64 μM) against drug-sensitive/resistant MTB strains, and they have acceptable safety indices against MTB H37Rv with the SI values of 4395 and 1405, respectively. Moreover, N-[2-(piperazin-1-yl)ethyl] moiety was also identified as a potentially alternative linker (compound 31), opening a new direction for further SAR studies.