81441-06-7

Basic information

• Product Name: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-
• CAS NO: 81441-06-7
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Mol File: 81441-06-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 287.7±25.0 °C(Predicted)
• Density: 1.027±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-(81441-06-7)
• EPA Substance Registry System: Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-(81441-06-7)

Safety Data

• Hazardous Substances Data: 81441-06-7(Hazardous Substances Data)

Upstream product

• 2832-19-1 2-Chloro-N-(hydroxymethyl)acetamide 
• 98-54-4 para-tert-butylphenol 

Downstream Products

• 81440-98-4 2-<<(2-aminoethyl)amino>methyl>-4-(1,1-dimethylethyl)-6-iodophenol dihydrochloride 
• 81441-07-8 2-<<(2-aminoethyl)amino>methyl>-4-(1,1-dimethylethyl)phenol dihydrochloride 
• 2725-53-3 2-hydroxy-5-t-butylbenzaldehyde 

Relevant articles and documents

Synthesis, attempted kinetic resolution and evaluation of [123I]-MK-447 analogues as inflammation radiopharmaceuticals

The non-steroidal anti-inflammatory agent 2-amino-methyl-4-tert-butyl-6-iodophenol hydrochloride (MK-447) and some of its analogues were labelled with 123I and tested in an inflamed rat-paw model. Even though MK-447 has a significant anti-inflammatory activity, and a 2.3 ratio for inflamed site over muscle, its usefullness for scintigraphic detection of inflammation is hindered by its high uptake in the skin. The kinetic resolution of diastereomeric products with chiral dienyl iron complexes was unsuccessful as the signals from the respective 1H and 13C NMR spectra were coincident.