81461-67-8

Basic information

• Product Name: N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea
• Synonyms: N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea
• CAS NO: 81461-67-8
• Molecular Weight: 292.789
• Mol File: 81461-67-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea(81461-67-8)
• EPA Substance Registry System: N-(4-chlorophenyl)-N’-(4-methoxyphenyl)thiourea(81461-67-8)

Safety Data

• Hazardous Substances Data: 81461-67-8(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 106-47-8 4-chloro-aniline 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 75-15-0 carbon disulfide 
• 10349-38-9 p-methoxyphenylisonitrile 
• 5470-34-8 4-methoxyformanilide 
• 1208-86-2 N-(4-methoxyphenyl)phenylamine 

Relevant articles and documents

Development of (4-methoxyphenyl)-1H-tetrazol-5-amine regioisomers as a new class of selective antitubercular agents

A series of halogenated (4-methoxyphenyl)-1H-tetrazol-5-amine regioisomers (1a-9a, 1b-9b) were synthesized from their corresponding thiourea analogues (1–9). The synthesis pathway was confirmed by an X-ray crystallographic studies of 1a, 1b and 5a. Title derivatives were tested for their in vitro antitubercular activity against standard, “wild-type” and atypical mycobacteria. The highest therapeutic potential was attributed to isomeric N-(bromophenyl)tetrazoles 8a and 9a. Their growth-inhibitory effect against multidrug-resistant Mycobacterium tuberculosis Spec. 210 was 8-16-fold stronger than that of the first-line tuberculostatics. Other new tetrazole-derived compounds were also more or equally effective towards that pathogen comparing to the established pharmaceuticals. Among non-tuberculous strains, Mycobacterium scrofulaceum was the most susceptible to the presence of the majority of tetrazole derivatives. The synergistic interaction was found between 9a and streptomycin, as well as the additivity of both 8a and 9a in pairs with isoniazid, rifampicin and ethambutol. None of the studied compounds displayed antibacterial or cytotoxic properties against normal and cancer cell lines, which indicated their highly selective antimycobacterial effects.

An isocyanide based multi-component reaction under catalyst- and solvent-free conditions for the synthesis of unsymmetrical thioureas

A new and efficient method for the synthesis of thiourea derivatives by a sequential one-pot, three-component reaction between aromatic isocyanides, amines, and 1,2-di-tert-butyldisulfane (DTBS) was developed and 27 different examples were synthesized in good to excellent yields. DTBS was identified as an effective sulfur surrogate without the use of both catalysts and solvents. This protocol does not employ any transition metal catalyst or special experimental setup.

Trapping Reactive Intermediates by Mechanochemistry: Elusive Aryl N-Thiocarbamoylbenzotriazoles as Bench-Stable Reagents

Monitoring of mechanochemical thiocarbamoylation by in situ Raman spectroscopy revealed the formation of aryl N-thiocarbamoylbenzotriazoles, reactive intermediates deemed unisolable in solution. The first-time isolation and structural characterization of these elusive molecules demonstrates the ability of mechanochemistry to access otherwise unobtainable intermediates and offers a new range of masked isothiocyanate reagents.