81462-48-8

Basic information

• Product Name: 2-vinylphenyl benzyl ketone
• Synonyms: 2-vinylphenyl benzyl ketone
• CAS NO: 81462-48-8
• Molecular Weight: 222.287
• Mol File: 81462-48-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-vinylphenyl benzyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-vinylphenyl benzyl ketone(81462-48-8)
• EPA Substance Registry System: 2-vinylphenyl benzyl ketone(81462-48-8)

Safety Data

• Hazardous Substances Data: 81462-48-8(Hazardous Substances Data)

Upstream product

• 24853-83-6 1-benzyl-3,4-dihydro-isoquinoline 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 77-78-1 dimethyl sulfate 
• 88-65-3 2-bromobenzoic-acid 
• 2142-69-0 2-bromophenyl methyl ketone 
• 34560-28-6 2-vinylbenzonitrile 
• 6921-34-2 benzylmagnesium chloride 
• 81462-35-3 (Z)-α-chloro-2-vinylstilbene 
• 26323-31-9 1-benzyl-3,4-dihydro-isoquinoline; hydrochloride 

Relevant articles and documents

Intramolecular One-Carbon Homologation of Unstrained Ketones via C-C Activation-Enabled 1,1-Insertion of Alkenes

Here, we describe the development of a Rh-catalyzed intramolecular one-carbon homologation of unstrained aryl ketones through a formal 1,1-insertion process of olefins, enabled by temporary directing group (TDG)-aided C-C activation. The reaction provides a distinct approach to access various substituted 1-indanones. Computational mechanistic studies reveal that the formal 1,1-insertion is realized by a selective C(sp2)-C(sp3) activation and turnover limiting 2,1-insertion into the alkene, followed by a facile β-H elimination and reinsertion process.