81474-47-7

Basic information

• Product Name: 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER;Methyl6-bromo-7-methoxybenzo[d][1,3]dioxole-5-carboxylate;1,3-Benzodioxole-5-carboxylic acid, 6-bromo-7-methoxy-, methyl ester
• CAS NO: 81474-47-7
• Molecular Formula: C₁₀H₉BrO₅
• Molecular Weight: 289.07946
• Mol File: 81474-47-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(81474-47-7)
• EPA Substance Registry System: 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER(81474-47-7)

Safety Data

• Hazardous Substances Data: 81474-47-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-7-methoxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester is a chemical compound with a molecular formula C10H9BrO5. It is a methyl ester derivative of benzo[1,3]dioxole-5-carboxylic acid, and it contains a bromine atom and a methoxy group attached to a dioxole ring. 6-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER has potential uses in organic synthesis and pharmaceutical research due to its unique structure and properties. Its synthesis and study may contribute to the development of new drugs and materials with diverse applications in the chemical and pharmaceutical industries.

Upstream product

• 109893-05-2 methyl 6-amino-7-methoxy-1,3-benzodioxole-5-carboxylate 
• 848772-95-2 methyl 2-bromo-3-methoxy-4,5-dihydroxybenzoate 
• 75-11-6 diiodomethane 
• 848772-89-4 methyl 2-bromo-3-hydroxy-4,5-methylenedioxybenzoate 
• 74-88-4 methyl iodide 
• 862251-79-4 6-bromo-7-hydroxy-2,2-diphenyl-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 848772-94-1 6-bromo-7-methoxy-2,2-diphenylbenzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 99-24-1 methyl galloate 
• 69829-46-5 methyl 7-hydroxy-2,2-diphenylbenzo[d]-1,3-dioxole-5-carboxylate 
• 79831-86-0 methyl 3-(benzyloxy)-4,5-dihydroxybenzoate 
• 116119-01-8 methyl 7-hydroxybenzo[d][1,3]dioxole-5-carboxylate 
• 142531-43-9 methyl 7-(benzyloxy)benzo[d][1,3]dioxole-5-carboxylate 
• 526221-05-6 2-ethoxy-7-hydroxy-benzo[1,3]dioxole-5-carboxylic acid methyl ester 

Downstream Products

• 870094-80-7 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxylic acid methyl ester 
• 870094-82-9 7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxole-5-carboxaldehyde 
• 870094-81-8 [7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]methanol 
• 870094-83-0 5-[7-methoxy-6-(3,4,5-trimethoxyphenyl)-benzo[1,3]dioxol-5-yl]-4-methyl-5H-furan-2-one 
• 139006-77-2 eupomatilone-3 
• 1084695-72-6 C₁₇H₁₄O₆ 

Relevant articles and documents

Gamma-bifendate intermediate, synthesis method thereof, and synthesis method of gamma-bifendate

The invention discloses a gamma-bifendate intermediate, a synthesis method thereof, and a synthesis method of gamma-bifendate. The gamma-bifendate intermediate is 4-methoxy-5, 6-methylenedioxy-2-methoxycarbonyl phenylboronic acid, and based on the gamma-bifendate intermediate, the invention further provides a novel synthesis method of gamma-bifendate. Ullmann reaction is not adopted, and Suzuki-Miyaura reaction is introduced as a key step of asymmetric synthesis, so that synthesis is simple, isomeride does not occur, the preparation process is optimized and upgraded, reaction steps are reduced, and reaction conditions are optimized.

Towards the Total Synthesis of Schisandrene: Stereoselective Synthesis of the Dibenzocyclooctadiene Lignan Core

A stereoselective synthesis of the dibenzocyclooctadiene lignan core of the natural product schisandrene is described. Starting from readily available gallic acid, the synthetic strategy involves Suzuki-Miyaura cross-coupling, Stille reaction, and ring-closing metathesis (RCM) in the reaction sequence. The required asymmetric center at C-7′ was established by an asymmetric reduction of a keto compound using the Corey-Bakshi-Shibata (CBS) catalyst. In our approach, the eight-membered ring was achieved by RCM for the first time.

An improved method for the synthesis of γ-DDB

A mild and efficient method for the synthesis γ-DDB has been developed through anhydride-linker assisted intramolecular Ullmann reaction. Highly regioselective bromination of differentially protected gallate was realized by virtue of the introduction of NBS.