81494-04-4

Basic information

• Product Name: 2-Chloro-N-(2-methoxy-benzyl)-acetamide
• Synonyms: 2-Chloro-N-(2-methoxy-benzyl)-acetamide;2-chloro-N-(2-methoxybenzyl)acetamide(SALTDATA: FREE)
• CAS NO: 81494-04-4
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66
• Mol File: 81494-04-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 392.1°C at 760 mmHg
• Flash Point: 191°C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 2.34E-06mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 2-Chloro-N-(2-methoxy-benzyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(2-methoxy-benzyl)-acetamide(81494-04-4)
• EPA Substance Registry System: 2-Chloro-N-(2-methoxy-benzyl)-acetamide(81494-04-4)

Safety Data

• Hazardous Substances Data: 81494-04-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-N-(2-methoxy-benzyl)-acetamide is a chemical compound with the molecular formula C10H12ClNO2. It is an organic compound with a chloride and a carbonyl functional group, as well as a benzyl and a methoxy group. 2-Chloro-N-(2-methoxy-benzyl)-acetamide is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is typically produced through the reaction of 2-chloroacetamide with 2-methoxybenzylamine. This chemical is known for its potential as a building block in the pharmaceutical industry and for its applications in organic synthesis. It is important to handle this compound with care and follow safety protocols when working with it.

InChI:InChI=1/C10H12ClNO2/c1-14-9-5-3-2-4-8(9)7-12-10(13)6-11/h2-5H,6-7H2,1H3,(H,12,13)

Upstream product

• 6850-57-3 2-methoxybenzylamine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 1241555-63-4 N-(2-methoxybenzyl)-2-[(3-methyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamide 
• 1241098-80-5 N-(2-methoxybenzyl)-2-[(3-phenyl-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetamide 

Relevant articles and documents

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library of putative M4 PAMs derived from VU0152100 and VU10005. These compounds investigate the pharmacological effects of previously identified methoxy and fluoro substituents, providing useful estimates of affinity (KB), cooperativity (αβ), and direct agonist properties (τB).