81540-92-3

Basic information

• Product Name: 4-methyl-2-phenacylpyridine 1-oxide
• CAS NO: 81540-92-3
• Molecular Weight: 227.263
• Mol File: 81540-92-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-2-phenacylpyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-phenacylpyridine 1-oxide(81540-92-3)
• EPA Substance Registry System: 4-methyl-2-phenacylpyridine 1-oxide(81540-92-3)

Safety Data

• Hazardous Substances Data: 81540-92-3(Hazardous Substances Data)

Upstream product

• 1122-45-8 2,4-dimethylpyridine N-oxide 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 3197-57-7 2-phenacyl-4-methylpyridine 
• 75834-96-7 2-(4-methyl(2-pyridyl))-1-phenylethan-1-ol 

Relevant articles and documents

SITE SELECTIVE EFFECT OF N-OXIDE FUNCTION TO METHYL GROUPS ON SIX-MEMBERED N-HETEROAROMATICS

Reaction of 2,4-dimethylpyridine 1-oxide with ethyl benzoate under basic conditions afforded 4-methyl-2-phenacylpyridine 1-oxide, while the same reaction of 2,4-dimethylpyridine itself is known to afford 2-methyl-4-phenacylpyridine.Concerning the above contrast, the effect of N-oxide function to the relative reactivity of the 2- and 4-methyl group was investigated on pyridine, quinoline, pyrimidine, and quinazoline homologues.The higher reactivity of α-methyl groups was concluded to be general in the N-oxides of these N-heteroaromatics.