81541-41-5

Basic information

• Product Name: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde
• Synonyms: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde
• CAS NO: 81541-41-5
• Molecular Weight: 284.702
• Mol File: 81541-41-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde(81541-41-5)
• EPA Substance Registry System: 3-(4-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-2-carbaldehyde(81541-41-5)

Safety Data

• Hazardous Substances Data: 81541-41-5(Hazardous Substances Data)

Upstream product

• 1788-93-8 3-(4-chlorophenyl)-2-methyl-3H-quinazolin-4-one 
• 118-92-3 anthranilic acid 
• 81541-40-4 R,S-N-(<3-<4-Chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-hydroxymethyl)acetamid 
• 22280-87-1 2-(chloromethyl)-3-(4-chlorophenyl)quinazolin-4(3H)-one 
• 80096-31-7 2-Azidomethyl-3-(4-chlorphenyl)-3,4-dihydro-4-chinazolinon 
• 81552-42-3 R,S-Essigsaeure(acetamido-<3-<4-chlorphenyl>-3,4-dihydro-4-oxo-2-chinazolinyl>-methyl)ester 

Downstream Products

• 131532-76-8 C₁₆H₁₂ClN₅OS 
• 131532-94-0 3-(4-Chloro-phenyl)-2-{[3-(4-chloro-phenyl)-4-phenyl-3H-thiazol-(2Z)-ylidene]-hydrazonomethyl}-3H-quinazolin-4-one 
• 131532-95-1 3-(4-Chloro-phenyl)-2-{[4-phenyl-3-p-tolyl-3H-thiazol-(2Z)-ylidene]-hydrazonomethyl}-3H-quinazolin-4-one 
• 131533-03-4 3-(4-Chloro-phenyl)-2-{[3-(4-chloro-phenyl)-4-oxo-thiazolidin-(2Z)-ylidene]-hydrazonomethyl}-3H-quinazolin-4-one 
• 131533-04-5 3-(4-Chloro-phenyl)-2-{[4-oxo-3-p-tolyl-thiazolidin-(2Z)-ylidene]-hydrazonomethyl}-3H-quinazolin-4-one 
• 131533-02-3 3-(4-Chloro-phenyl)-2-{[4-oxo-3-phenyl-thiazolidin-(2Z)-ylidene]-hydrazonomethyl}-3H-quinazolin-4-one 
• 131533-01-2 2-{[3-Butyl-4-oxo-thiazolidin-(2Z)-ylidene]-hydrazonomethyl}-3-(4-chloro-phenyl)-3H-quinazolin-4-one 
• 131532-81-5 C₂₃H₁₈ClN₅OS 
• 131532-80-4 C₂₂H₁₆ClN₅OS 
• 131532-79-1 C₂₀H₂₀ClN₅OS 
• 131532-77-9 C₁₇H₁₄ClN₅OS 
• 131532-82-6 C₂₂H₁₅Cl₂N₅OS 
• 131532-78-0 C₁₉H₁₆ClN₅OS 

Relevant articles and documents

Synthesis, Characterization, and Biological Evaluation of Novel 3-(4-Chlorophenyl)-2-(substituted)quinazolin-4(3H)-one Derivatives as Multi-target Anti-inflammatory Agents

A novel class of 3-(4-chlorophenyl)-2-(substituted)quinazolin-4(3H)-one derivatives were synthesized, and the structure of synthesized compounds was characterized by IR, 1H NMR, and mass spectroscopy. The newly synthesized compounds (4a–g and 6a–g) were tested for their in vitro cyclooxygenase (COX) inhibition activity. The compounds have inhibitory profile against both COX-1 and COX-2, and some of the compounds are found to be selective against COX-2. The compound 6g showed distinct inhibitory activity on COXs. The synthesized compounds were evaluated for their potential anti-inflammatory activity as inhibitors of the proinflammatory cytokines IL-6. Compounds 4d–g showed the highest level of inhibition among all the tested compounds. Thus, our data suggested that these compounds may represent a new class of potent anti-inflammatory agents.