81574-59-6

Basic information

• Product Name: 2,4,6-trimethoxy-3-methylphenol
• Synonyms: 2,4,6-trimethoxy-3-methylphenol
• CAS NO: 81574-59-6
• Molecular Weight: 198.219
• Mol File: 81574-59-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4,6-trimethoxy-3-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-trimethoxy-3-methylphenol(81574-59-6)
• EPA Substance Registry System: 2,4,6-trimethoxy-3-methylphenol(81574-59-6)

Safety Data

• Hazardous Substances Data: 81574-59-6(Hazardous Substances Data)

Upstream product

• 4619-74-3 2,4,6-tribromo-m-cresol 
• 124-41-4 sodium methylate 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 621-23-8 1,2,3-trimethoxybenzene 
• 81574-58-5 2,4,6-trimethoxy-3-methylbenzaldehyde 
• 14107-97-2 2,4,6-trimethoxytoluene 

Downstream Products

• 81574-61-0 methyl 6-(4-hydroxy-2,6-dimethoxy-3-methylphenoxy)-2,4-dimethoxy-3-methylbenzoate 
• 74628-39-0 methyl 2,4-dimethoxy-6-(2,4,6-trimethoxy-3-methylphenoxy)-3-methylbenzoate 

Relevant articles and documents

A ligand-free, powerful, and practical method for methoxylation of unactivated aryl bromides by use of the CuCl/HCOOMe/MeONa/MeOH system

A ligand-free, powerful, and practical method for mono and polymethoxylation of unactivated aryl bromides has been developed; CuCl was used as catalyst, HCOOMe as cocatalyst, and methanolic MeONa as both nucleophile and solvent. This eco-friendly procedure is characterized by operational simplicity, inexpensive substrates (unactivated mono to polybromoarenes), full conversion, and direct recovery of pure MeOH.

Depsidone Synthesis. Part 21. A New Synthesis of Grisa-2',5'-diene-3,4'-diones

Treatment of suitably substituted methyl 2-phenoxybenzoates with titanium(IV) chloride and dry hydrogen chloride afforded grisa-2',5'-diene-3,4'-diones in high yield.The structures of these compounds followed from their thermal stability, their methanolysis to methyl 2-(4-hydroxyphenoxy)benzoates, and their reductive cleavage to 2,4'-dihydrobenzophenones.Treatment of the benzophenones with base gave xanthones.An attempt to synthesize dehydrogriseofulvin (1) by this method failed.