81577-11-9

Basic information

• Product Name: 1-(3-chlorophenyl)-2,2,2-trifluoroethanol
• Synonyms: 1-(3-chlorophenyl)-2,2,2-trifluoroethanol
• CAS NO: 81577-11-9
• Molecular Formula: C₈H₆ClF₃O
• Molecular Weight: 210.5808496
• Mol File: 81577-11-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-chlorophenyl)-2,2,2-trifluoroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chlorophenyl)-2,2,2-trifluoroethanol(81577-11-9)
• EPA Substance Registry System: 1-(3-chlorophenyl)-2,2,2-trifluoroethanol(81577-11-9)

Safety Data

• Hazardous Substances Data: 81577-11-9(Hazardous Substances Data)

Usage

General Description

1-(3-chlorophenyl)-2,2,2-trifluoroethanol is a chemical compound that consists of a trifluoroethyl group attached to a chlorophenyl group on a carbon atom, with a hydroxyl group attached to the same carbon atom. It is commonly used in organic synthesis and is a versatile building block for the preparation of various pharmaceuticals and agrochemicals. It is also used as a solvent in the pharmaceutical and manufacturing industries. The trifluoroethanol group provides strong hydrogen-bond donating properties, making it useful for promoting certain chemical reactions. Additionally, the chlorophenyl group enhances the compound's reactivity and selectivity in organic reactions.

Upstream product

• 108-37-2 1-bromo-3-chlorobenzene 
• 383-63-1 ethyl trifluoroacetate, 
• 321-31-3 1-(3-chlorophenyl)-2,2,2-trifluoroethanone 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 587-04-2 m-Chlorobenzaldehyde 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 862731-93-9 2-[1-(3-chlorophenyl)-2,2,2-trifluoroethoxy]-1,3,2-benzodioxaphospholene 
• 1226502-97-1 2-chloro-N-{3-[2,2,2-trifluoro-1-(3-chlorophenyl)ethoxy]-quinoxalin-2-yl}benzenesulfonamide 
• 321-31-3 1-(3-chlorophenyl)-2,2,2-trifluoroethanone 

Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).