81616-11-7Relevant articles and documents
Amino-Protecting Reagents: New Promising Reagents for tert-Butoxycarbonylation, Benzyloxycarbonylation, and carbonylation
Kita, Yasuyuki,Haruta, Jun-ichi,Yasuda, Hitoshi,Fukunaga, Keiko,Shirouchi, Yoshiaki,Tamura, Yasumitsu
, p. 2697 - 2700 (1982)
A new method for the preparation of tert-butyl- (1d), benzyl- (1e), and (β-trimethylsilyl)ethyl α-methoxyvinyl carbonates (1f) has been devised.The reaction of these reagents with amino compounds proceeds rapidly under mild conditions to give the corresponding N-tert-butoxycarbonylated (N-Boc), N-benzyloxycarbonylated (N-Z), and N-carbonylated (N-Tmseoc) compounds in quantitative yields.Twenty-two examples using amines, amino alcohols, and amino acids were presented.