81631-72-3

Basic information

• Product Name: Hexanedioic acid, 2-phenyl-, dimethyl ester
• CAS NO: 81631-72-3
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol File: 81631-72-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Hexanedioic acid, 2-phenyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanedioic acid, 2-phenyl-, dimethyl ester(81631-72-3)
• EPA Substance Registry System: Hexanedioic acid, 2-phenyl-, dimethyl ester(81631-72-3)

Safety Data

• Hazardous Substances Data: 81631-72-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 1515-78-2 buta-1,3-dien-1-ylbenzene 
• 3878-55-5 methyl hydrogen succinate 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 492-38-6 2-phenylacrylic acid 
• 4144-62-1 5-benzoylvaleric acid 
• 149-73-5 trimethyl orthoformate 
• 109-99-9 tetrahydrofuran 
• 186581-53-3 diazomethane 
• 64740-47-2 4-phenylbutyl lithium 

Relevant articles and documents

Photocatalytic Hydromethylation and Hydroalkylation of Olefins Enabled by Titanium Dioxide Mediated Decarboxylation

A versatile method for the hydromethylation and hydroalkylation of alkenes at room temperature is achieved by using the photooxidative redox capacity of the valence band of anatase titanium dioxide (TiO2). Mechanistic studies support a radical-based mechanism involving the photoexcitation of TiO2 with 390 nm light in the presence of acetic acid and other carboxylic acids to generate methyl and alkyl radicals, respectively, without the need for stoichiometric base. This protocol is accepting of a broad scope of alkene and carboxylic acids, including challenging ones that produce highly reactive primary alkyl radicals and those containing functional groups that are susceptible to nucleophilic substitution such as alkyl halides. This methodology highlights the utility of using heterogeneous semiconductor photocatalysts such as TiO2 for promoting challenging organic syntheses that rely on highly reactive intermediates.

Ni-Catalyzed Site-Selective Dicarboxylation of 1,3-Dienes with CO2

A site-selective catalytic incorporation of multiple CO2 molecules into 1,3-dienes en route to adipic acids is described. This protocol is characterized by its mild conditions, excellent chemo- and regioselectivity and ease of execution under CO2 (1 atm), including the use of bulk butadiene and/or isoprene feedstocks.

Carbanion Rearrangements by Intramolecular 1,ω Proton Shifts, III. The Reaction of 2-, 3-, 4-, and 5-Phenylalkyllithium Compounds

Upon addition of THF to a solution of 4-phenylbutyllithium (2) in diethyl ether a rapid intramolecular 1,4 proton shift takes place with the formation of 1-phenylbutyllithium (5).Similarly, although somewhat more slowly, 5-phenylpentyllithium (82) rearranges to 1-phenylpentyllithium (83) via 1,5 proton transfer.The corresponding rearrangements by 1,2 or 1,3 hydrogen shifts, however, starting with 2-phenylethyllithium (1) and 3-phenylpropyllithium (54), respectively, were not detected.With 3-phenylpropyllithium (54) a slow intramolecular 1,5 transfer an ortho proton is observed instead, yielding o-propylphenyllithium (100).The corresponding 1,6 shift with 4-phenylbutyllithium (2) was also detected in a minor amount in addition to the 1,4 proton shift already mentioned.There is no indication, however, for a 1,4 transfer of an ortho proton in 2-phenylethyllithium (1).The reaction products in this case can be exclusively explained by intermolecular transmetallation reactions.All ω-phenylalkyllithium compounds under investigation show interesting side and secondary reactions being rather different in deuterated solvents and in deuteriumfree solvents, respectively, due to the isotope effects.The analysis of the products is accomplished by 1H-NMR spectroscopy and, after derivatization, with the help of a GC-MS-combination.Stereoelectronic reasons are made responsible for the failure of the intramolecular 1,2 and 1,3 proton shift in these systems.