81684-13-1Relevant articles and documents
NMR Spectra and Stereochemistry of Perhydrooxazolopyridines
Crabb, Trevor A.,Trethewey, Andrew N.,Takeuchi, Yoshito
, p. 345 - 347 (1988)
Low-temperature 13C and 1H NMR spectra show perhydrooxazolopyridine to exist in CDCl3-CFCl3 solution at 183 K as an equilibrium between 73percent trans-fused and 27percent O-inside cis-fused conformers. cis-(H-1, H-8a)-1-Alkylperhydrooxazolopyridines (alkyl=methyl, ethyl, isopropyl) adopt equilibria heavily biased towards the trans-fused conformers, whereas the epimers adopt 18percent O-inside cis-fused -->/pyridine adopts an equilibrium containing ca 3percent trans-fused conformer in equilibrium with 97percent O-inside cis-fused conformer.