817204-22-1Relevant articles and documents
Spirodiepoxides in total synthesis: Epoxomicin
Katukojvala, Sreenivas,Barlett, Kristin N.,Lotesta, Stephen D.,Williams, Lawrence J.
, p. 15348 - 15349 (2007/10/03)
The first use of the spirodiepoxide functional group in total synthesis, a study culminating in an efficient synthesis of the potent proteasome inhibitor epoxomicin, is described. Spirodiepoxides derived from allenes by oxidation are shown to give syn dis