81743-88-6 Usage
Chemical Structure
Contains a benzene ring fused to an isoselenazol ring, with a carbonyl group at position 3 and a 4-methylphenyl group at position 2.
Antioxidative Properties
Ebselen has been shown to have antioxidant properties, which can help protect cells from damage caused by reactive oxygen species (ROS).
Anti-Inflammatory Properties
Ebselen has demonstrated anti-inflammatory effects, which can be beneficial in reducing inflammation associated with various diseases and conditions.
Potential Applications
Ebselen has been studied for its potential use in treating a range of diseases and conditions, including cancer, stroke, dementia, and psychiatric disorders.
Neuroprotective Effects
Ebselen has shown neuroprotective effects, which can be useful in protecting the brain and nervous system from damage.
Antiviral Activity
Ebselen has been investigated for its potential antiviral activity, which could be useful in the development of new treatments for viral infections.
Protection Against Oxidative Stress
Ebselen has been studied for its potential use in protecting against oxidative stress, which can contribute to the development of various diseases and conditions.
Inflammation Reduction
Ebselen has been investigated for its potential to reduce inflammation, which can be beneficial in the treatment of various inflammatory diseases.
Research and Development
Ebselen is a promising candidate for further research and development in the fields of medicine and pharmacology due to its various potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 81743-88-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,7,4 and 3 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 81743-88:
(7*8)+(6*1)+(5*7)+(4*4)+(3*3)+(2*8)+(1*8)=146
146 % 10 = 6
So 81743-88-6 is a valid CAS Registry Number.
InChI:InChI=1/C14H11NOSe/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
81743-88-6Relevant articles and documents
Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis
Cao, Hongxuan,Chen, Han,Han, Xinya,Huang, Yunyuan,Liu, Jiaqi,Peng, Chao,Rao, Li,Ren, Yanliang,Sheng, Chunquan,Su, Chen,Tu, Jie,Wan, Chen,Wan, Jian,Wen, Wuqiang
, p. 2656 - 2674 (2022/02/09)
Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover a novel covalent binding site (C292 site) and the first-in-class covalent allosteric inhibitors
Benzisoselenazolone derivative and preparation method and application thereof
-
, (2022/01/05)
The invention provides a benzisoselenazolone derivative and a preparation method and application thereof. The compound has a structure as shown in a formula I. The invention further relates to a preparation method of the compound with the structure shown in the formula I, a pharmaceutical composition and application of the compound in preparation of anti-SARS-CoV-2Mpro drugs.
Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties
Pietka-Ottlik, Magdalena,Burda-Grabowska, Ma?gorzata,Wo?na, Marta,Waleńska, Joanna,Kaleta, Rafa?,Zaczyńska, Ewa,Piasecki, Egbert,Giurg, Miros?aw
, p. 546 - 556 (2017/03/14)
A series of new mono and disubstituted alkylated and methoxylated benzisoselanzol-3(2H)-ones and bis(2-carbamoylaryl)diselenides were prepared in yields ranging from 55% to 95% starting from anthranilic acid and were evaluated for antiviral and antimicrobial activity. The compounds exhibited antiviral activity against Human herpes virus 1 and Encephalomyocarditis virus as well as antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Candida albicans. (Chemical Equation Presented).
