81822-46-0

Basic information

• Product Name: Benzoic acid, 5-fluoro-2-[(1-methylethyl)amino]-
• Synonyms: 5-Fluoro-2-isopropylamino-benzoic acid
• CAS NO: 81822-46-0
• Molecular Formula: C10H12FNO2
• Molecular Weight: 197.209
• Mol File: 81822-46-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 144 - 146 °C (H2O)
• CAS DataBase Reference: Benzoic acid, 5-fluoro-2-[(1-methylethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-fluoro-2-[(1-methylethyl)amino]-(81822-46-0)
• EPA Substance Registry System: Benzoic acid, 5-fluoro-2-[(1-methylethyl)amino]-(81822-46-0)

Safety Data

• Hazardous Substances Data: 81822-46-0(Hazardous Substances Data)

Upstream product

• 75-30-9 2-iodo-propane 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 81822-27-7 2-(2-Chloro-phenyl)-6-fluoro-1-isopropyl-1H-quinazolin-4-one 
• 81822-26-6 6-Fluoro-1-isopropyl-2-phenyl-1H-quinazolin-4-one 
• 81822-47-1 5-fluoro-2-(isopropylamino)benzamide 

Relevant articles and documents

Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives

A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isoproyl-(2-fluorophenyl)-4(1H)-quinazolinone.