81831-55-2

Basic information

• Product Name: ((1R,5R)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester
• CAS NO: 81831-55-2
• Molecular Weight: 198.305
• Mol File: 81831-55-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((1R,5R)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((1R,5R)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester(81831-55-2)
• EPA Substance Registry System: ((1R,5R)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester(81831-55-2)

Safety Data

• Hazardous Substances Data: 81831-55-2(Hazardous Substances Data)

Upstream product

• 57093-62-6 cyano(4-methylcyclohexyl)acetic acid ethyl ester 
• 114183-27-6 ethyl 3,3,5-trimethylcyclohexylcyanoacetate 
• 186581-53-3 diazomethane 
• 3213-73-8 3,3,5-trimethylcyclohexane-1-acetic acid 

Relevant articles and documents

Stereochemistry of 1,4-Addition of Nucleophiles to Ethyl Cyclohexylidenecyanoacetates

The stereochemistry of 1,4-addition of several nucleophiles such as cyanide, sodium borohydride, and methylmagnesium iodide to three substituted ethyl cyclohexylidenecyanoacetates (1-3) has been determined.A higher preference for equatorial attack is observed in these compounds than in related cyclohexanones, which is considerably diminished by the use of aprotic polar solvents.The results do not show any appreciable contribution of product stability control, recently shown to be important for hydride reduction of cyclohexanones, and have been rationalized on thebasis of a six-center cyclic transition state in which steric factors play a dominant role.These compounds have also been reduced by catalytic hydrogenation (Pd/C), and, interestingly, with unhindered systems (1, 2) hydrogenation takes place more from the axial side (40-60percent) as compared to cyclohexanones.