81837-98-1

Basic information

• Product Name: benzamide, N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-
• Synonyms: benzamide, N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-;N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]benzamide
• CAS NO: 81837-98-1
• Molecular Formula: C₁₀H₁₀N₄OS
• Molecular Weight: 234.2776
• Mol File: 81837-98-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzamide, N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: benzamide, N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-(81837-98-1)
• EPA Substance Registry System: benzamide, N-[(5-amino-1,3,4-thiadiazol-2-yl)methyl]-(81837-98-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 81837-98-1(Hazardous Substances Data)

Upstream product

• 83530-35-2 1-hippuroyl thiosemicarbazide 
• 2443-68-7 (2-hydrazinyl-2-oxoethyl)benzamide 
• 495-69-2 Hippuric Acid 
• 79-19-6 thiosemicarbazide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 59079-33-3 5-aminomethyl-[1,3,4]thiadiazol-2-ylamine 
• 83530-94-3 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-p-anisylacetonitrile 
• 83530-89-6 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-2-hydroxyphenylacetonitrile 
• 83530-87-4 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-m-nitrophenylacetonitrile 
• 83530-86-3 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-phenylacetonitrile 
• 83530-92-1 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-(4-hydroxy-3-methoxyphenyl)acetonitrile 
• 83530-90-9 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-(3-bromo-2-hydroxyphenyl)acetonitrile 
• 83530-91-0 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-(3,5-dibromo-2-hydroxyphenyl)acetonitrile 

Relevant articles and documents

Microwave-assisted facile synthesis, anticancer evaluation and docking study of N-((5-(substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) benzamide derivatives

In the present work, 12 novel Schiff’s bases containing a thiadiazole scaffold and benzamide groups coupled through appropriate pharmacophore were synthesized. These moieties are associated with important biological properties. A facile, solvent-free synthesis of a series of novel 7(a–l) N-((5-(substituted methylene amino)-1,3,4-thiadiazol-2-yl)methyl) benzamide was carried out under microwave irradiation. Structures of the synthesized compounds were confirmed by IR, NMR, mass spectral study and elemental analysis. All the synthesized hybrids were evaluated for their in vitro anticancer activity against a panel of four human cancer cell lines, viz. SK-MEL-2 (melanoma), HL-60 (leukemia), HeLa (cervical cancer), MCF-7 (breast cancer) and normal breast epithelial cell (MCF-10A) using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay method. Most of the synthesized compounds exhibited promising anticancer activity, showed comparable GI50 values comparable to that of the standard drug Adriamycin. The compounds 7k, 7l, 7b, and 7a were found to be the most promising anticancer agents in this study. A molecular docking study was performed to predict the probable mechanism of action and computational study of the synthesized compounds 7(a–l) was performed to predict absorption, distribution, metabolism, excretion and toxicity (ADMET) properties, by using QikProp v3.5 (Schr dinger LLC). The results showed the good oral drug-like behavior of the synthesized compounds 7(a–l).

Studies on acetamide derivatives: preparation and antimicrobial activity of 2 α-arylaminoacetamido/α-carbamoyl benzylamino/arylcarbamoylmethylamino-5-o-nitrophenyl/benzoylaminomethyl-1,3, 4-thiadiazole

-