81860-76-6

Basic information

• Product Name: Piperidine, 1-[(4-methoxyphenyl)acetyl]-
• CAS NO: 81860-76-6
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• Mol File: 81860-76-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[(4-methoxyphenyl)acetyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[(4-methoxyphenyl)acetyl]-(81860-76-6)
• EPA Substance Registry System: Piperidine, 1-[(4-methoxyphenyl)acetyl]-(81860-76-6)

Safety Data

• Hazardous Substances Data: 81860-76-6(Hazardous Substances Data)

Upstream product

• 99955-80-3 N-<2-(4-Methoxyphenyl)-1-thioxoethyl>piperidine 
• 110-89-4 piperidine 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 2591-86-8 N-Formylpiperidine 
• 768-60-5 4-methoxyphenylacetylen 
• 81860-68-6 3-(4-methoxyphenyl)-oxiranecarbonitrile 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 13683-85-7 1-(4-methoxystyryl)piperidine 
• 13683-85-7 (E)-1-(2-(4-methoxyphenyl)ethenyl)piperidine 
• 1322058-65-0 4-(1-oxo-1-(piperidin-1-yl)hexan-2-yl)phenyl acrylate 
• 1322058-62-7 1-(piperidin-1-yl)-2-(4-(2-(trimethylsilyl)ethoxy)phenyl)hexan-1-one 
• 1322058-61-6 2-(4-(1-oxo-1-(piperidin-1-yl)hexan-2-yl)phenoxy)acetic acid 
• 1322058-59-2 methyl 2-(4-(1-oxo-1-(piperidin-1-yl)hexan-2-yl)phenoxy)acetate 
• 1322058-64-9 2-(4-(1-oxo-1-(piperidin-1-yl)hexan-2-yl)phenoxy)ethyl acetate 
• 1322058-63-8 2-(4-(2-hydroxyethoxy)phenyl)-1-(piperidin-1-yl)hexan-1-one 
• 1322058-54-7 4-(1-oxo-1-(piperidin-1-yl)hexan-2-yl)phenyl acetate 
• 1322058-55-8 2-(4-hydroxyphenyl)-1-(piperidin-1-yl)hexan-1-one 
• 1322058-68-3 2-(4-methoxy)phenyl-(1-piperidin-1-yl)hexanone 
• 865874-22-2 1-(1-(4-methoxyphenyl)ethyl)piperidine 
• 130198-64-0 1-[1-(4-Methoxy-phenyl)-2-piperidin-1-yl-ethyl]-cyclohexanol 
• 114393-72-5 (Z)-Methyl <2-(4-Methoxyphenyl)-1-(methylthio)ethylidene>hydrazinocarboxylate 

Relevant articles and documents

Direct defluorinative amidation-hydrolysis reaction of gem-difluoroalkenes with N,N-dimethylformamide, and primary and secondary amines

A novel and efficient method for the synthesis of arylacetamides by the reactions of gem-difluoroalkenes with N,N-dialkylformamides, and primary and secondary amines with the assistance of KOtBu and water was developed.

Direct use of dioxygen as an oxygen source: Catalytic oxidative synthesis of amides

The first transition-metal-catalyzed direct oxidative synthesis of amides by using dioxygen as an oxygen source has been developed under mild conditions, in which DBU was used as the key additive. The present methodology, which utilizes dioxygen as an oxidant and oxygen source and cheap copper salts as catalysts, opens up an interesting and attractive avenue for the synthesis of amide functionality.

A facile one-carbon homologation of aryl aldehydes to amides.

The easily accessible 2-aryl-1,1-dibromo-1-alkenes can be converted to amides under unusually mild conditions in good to excellent yields. Both electron-donating and electron-withdrawing substitutions on the aromatic rings are tolerated, and the reaction works well with hindered alkylamines. This simple homologation could find broad applications. [reaction: see text]