81925-36-2Relevant articles and documents
A SIMPLIFIED ISOQUINOLINE SYNTHESIS
Boger, Dale L.,Brotherton, Christine E.,Kelley, Marshall D.
, p. 3977 - 3980 (2007/10/02)
A simple variation of the Pomeranz-Fritsch cyclization provides a short, efficient route to isoquinolines.Treatment of benzylic halides or mesylates 1 with the sodium anion of N-tosyl aminoacetaldehyde dimethyl acetal (2) followed by acid-catalyzed cyclization provides an effective, two-step preparation of isoquinolines 4.