81930-33-8Relevant articles and documents
Synthesis and preliminary biological activity of some new pyrazole derivatives as acyclonucleoside analogues
Radi, Smaail,Salhi, Souad,Radi, Amal
experimental part, p. 27 - 30 (2010/12/19)
Some novel pyrazole acyclonucleosides were prepared through binding of pyrazole-3,5-substituted derivatives with acyclic substituents mimetizing individual fragments of the ribose ring such as: 1-[(2-hydroxyethoxy) methyl], 1-[4-(hydroxybutyl)], 1-[3-(hydroxypropyl)] and 1-[(2-hydroxyethyl amino) methyl]. Their syntheses were performed from easily accessible starting materials. The prepared compounds were evaluated for their antibacterial activity. Structure-activity relationship studies (SAR) indicate that introduction of modified arm in N1 position of pyrazole moieties has not any impact on the biolgical activity.