81930-38-3

Basic information

• Product Name: 1,3-Cyclohexanedione, 2-acetyl-5-methyl-
• CAS NO: 81930-38-3
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Mol File: 81930-38-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Cyclohexanedione, 2-acetyl-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Cyclohexanedione, 2-acetyl-5-methyl-(81930-38-3)
• EPA Substance Registry System: 1,3-Cyclohexanedione, 2-acetyl-5-methyl-(81930-38-3)

Safety Data

• Hazardous Substances Data: 81930-38-3(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

It is a modified version of the parent compound, cyclohexanedione, with additional functional groups.

Explanation

The compound is utilized in the production of various pharmaceuticals and organic compounds due to its reactivity and reducing properties.

Explanation

The compound exists in a liquid state and has a yellowish color.

Explanation

The compound has a noticeable and sweet-smelling odor.

Explanation

The compound can dissolve in water, alcohol, and ether, which are common solvents used in chemical reactions and laboratory procedures.

Explanation

The compound is known for its strong reducing properties, allowing it to react with other chemicals to form a variety of products.

Explanation

Due to its reactivity and potential hazards, it is essential to take necessary safety measures when working with 1,3-Cyclohexanedione, 2-acetyl-5-methylin a laboratory setting.

Derivative of cyclohexanedione

Yes

Common use

Synthesis of pharmaceuticals and organic compounds

Physical state

Yellowish liquid

Odor

Strong, sweet

Solubility

Soluble in water, alcohol, and ether

Chemical reactivity

Powerful reducing agent

Safety precautions

Handle with caution and follow proper safety protocols

Upstream product

• 626-51-7 3-methyl glutaric acid 
• 75-36-5 acetyl chloride 
• 96626-00-5 5-methyl-3-oxocyclohex-1-en-1-yl acetate 
• 4341-24-6 5-methylcyclohexan-1,3-dione 
• 110-89-4 piperidine 
• 123-54-6 acetylacetone 
• 108-24-7 acetic anhydride 

Downstream Products

• 31405-63-7 1-(2-hydroxy-6-methoxy-4-methylphenyl)ethanone 
• 1473453-17-6 N-[3-(3,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindol-1-yl)-4-phenoxyphenyl]methanesulfonamide 
• 1473453-15-4 1-(5-amino-2-phenoxyphenyl)-3,6-dimethyl-2,5,6,7-tetrahydro-4H-isoindol-4-one 
• 1473453-11-0 3,6-dimethyl-1-(2-phenoxyphenyl)-2,5,6,7-tetrahydro-4H-isoindol-4-one 
• 129793-14-2 2-ethyl-5-methylcyclohexane-1,3-dione 
• 131846-38-3 2-(3-diethylamino-2-propenoyl)-5-methyl-1,3-cyclohexanedione 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 81930-40-7 1,5,6,7-Tetrahydro-3,6-dimethyl-1-<3-(p-tolylsulfonyloxy)propyl>-4H-indazol-4-on 

Relevant articles and documents

Tetrahydroindazole inhibitors of CDK2/cyclin complexes

Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogues 53 and 59 showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogues to a CDK2/cyclin complex is favored over binding to free CDK2. Computational analysis was used to predict a potential binding site at the CDK2/cyclin E1 interface.

SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS

The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.

Antiviral and Antimicrobial Activity of 2,4-Diacylphloroglucinols, 2-Acylcyclohexane-1,3-diones and 2-Carboxamidocyclohexane-1,3-diones

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