81947-89-9

Basic information

• Product Name: 1-(tert-butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol
• Synonyms: 1-(tert-butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol;1-[2-(6-Chloro-3-pyridazinyl)phenoxy]-3-[(1,1-dimethylethyl)amino]-2-propanol;Einecs 279-855-9
• CAS NO: 81947-89-9
• Molecular Formula: C17H22ClN3O2
• Molecular Weight: 335.82848
• EINECS: 279-855-9
• Mol File: 81947-89-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 538.5°Cat760mmHg
• Flash Point: 279.5°C
• Appearance: /
• Density: 1.187g/cm³
• Vapor Pressure: 1.99E-12mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 1-(tert-butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol(81947-89-9)
• EPA Substance Registry System: 1-(tert-butylamino)-3-[2-(6-chloropyridazin-3-yl)phenoxy]propan-2-ol(81947-89-9)

Safety Data

• Hazardous Substances Data: 81947-89-9(Hazardous Substances Data)

Usage

Type of Drug

Beta-blocker medication

Purpose

Treats high blood pressure, improves survival after a heart attack, and prevents migraine headaches

Mechanism of Action

Blocks the action of certain natural substances (e.g., epinephrine) on the heart and blood vessels, lowering blood pressure and decreasing the workload on the heart

Administration

Usually taken by mouth

Side Effects

Dizziness, fatigue, and difficulty sleeping

Precaution

Follow dosage instructions provided by a healthcare professional

Chemical Structure

Contains a tert-butylamino group, a phenoxy group connected to a 6-chloropyridazin-3-yl group, and a secondary alcohol (-OH) group

Molecular Weight

Approximately 361.86 g/mol

Appearance

Nebivolol is a white to off-white crystalline powder

Solubility

Soluble in ethanol, slightly soluble in water, and practically insoluble in heptane

Stability

Stable under normal temperature and pressure conditions, but should be stored in a tight, light-resistant container

Drug Interactions

May interact with other medications, including other beta-blockers, calcium channel blockers, and certain antidepressants

Breastfeeding

It is unknown whether nebivolol passes into breast milk, so caution should be exercised when administered to nursing mothers

Metabolism

Metabolized in the liver by the cytochrome P450 system, primarily by the CYP2D6 enzyme

Excretion

Eliminated primarily in the urine, with a smaller portion excreted in the feces

Half-life

Approximately 12-24 hours in healthy adults

InChI:InChI=1/C17H22ClN3O2/c1-17(2,3)19-10-12(22)11-23-15-7-5-4-6-13(15)14-8-9-16(18)21-20-14/h4-9,12,19,22H,10-11H2,1-3H3

Relevant articles and documents

PROCESS FOR PREPARING 3-CHLORO-6-(2-HYDROXYPHENYL)-PYRIDAZINES

A process for preparing 3-chloro-6-(2-hydroxyphenyl) pyridazines by the reaction of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones with phosphorus oxychloride and a disubstituted formamide. The chloropyridazine compounds are useful intermediates for preparing co