81958-21-6

Basic information

• Product Name: 4-chloro-N-(4-sulfamoylphenyl)butanamide
• CAS NO: 81958-21-6
• Molecular Formula: C₁₀H₁₃ClN₂O₃S
• Molecular Weight: 276.7398
• Mol File: 81958-21-6.mol
• Article Data: 4

Chemical Properties

• Density: 1.412g/cm³
• Refractive Index: 1.592
• CAS DataBase Reference: 4-chloro-N-(4-sulfamoylphenyl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(4-sulfamoylphenyl)butanamide(81958-21-6)
• EPA Substance Registry System: 4-chloro-N-(4-sulfamoylphenyl)butanamide(81958-21-6)

Safety Data

• Hazardous Substances Data: 81958-21-6(Hazardous Substances Data)

Upstream product

• 63-74-1 sulfanilamide 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 36090-27-4 4-(2-oxopyrrolidinyl)benzenesulfonamide 

Relevant articles and documents

Compound capable of inhibiting activity of NEDD8 kinase as well as preparation method and pharmaceutical application of compound

The invention belongs to the field of medicines and in particular relates to a compound with the structure of a formula I, a stereomer of the compound or pharmaceutically acceptable salts of the compound as well as a preparation method of the compound and application of the compound to preparation of anti-tumor medicines. A pharmacological experiment result shows that the compound can be used for inhibiting the activity of NEDD8 kinase and has the inhibition effect on proliferation of a plurality of types of tumor cells, so that the compound can be used as an NEDD8 kinase activity inhibitor for preparing the anti-tumor medicines. The formula I is shown in the description.

Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX

A series of sulfonamides has been obtained by reacting sulfanilamide or 5-amino-1,3,4-thiadiazole-2-sulfonamide with ω-chloroalkanoyl chlorides, followed by replacement of the ω-chlorine atom with secondary amines. Tails incorporating heterocyclic amines belonging to the morpholine, piperidine and piperazine ring systems have been attached to these sulfonamides, by means of an alkanoyl-carboxamido linker containing from two to five carbon atoms. The new derivatives prepared in this way were tested as inhibitors of three carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic isozymes CA I and II, and the catalytic domain of the transmembrane, tumor-associated isozyme CA IX. Several low nanomolar CA I and CA II inhibitors were detected both in the aromatic and heterocyclic sulfonamide series, whereas the best hCA IX inhibitors (inhibition constants in the range of 22-35 nM) all belonged to the acetazolamide-like derivatives.