81968-77-6

Basic information

• Product Name: 4α-Hydroxyadamantane-1-carboxylic acid
• Synonyms: 4α-Hydroxyadamantane-1-carboxylic acid
• CAS NO: 81968-77-6
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24294
• Mol File: 81968-77-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 117-128 °C(mixture of isomers)
• Boiling Point: 366.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.368±0.06 g/cm3(Predicted)
• PKA: 4.66±0.40(Predicted)
• CAS DataBase Reference: 4α-Hydroxyadamantane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4α-Hydroxyadamantane-1-carboxylic acid(81968-77-6)
• EPA Substance Registry System: 4α-Hydroxyadamantane-1-carboxylic acid(81968-77-6)

Safety Data

• Hazardous Substances Data: 81968-77-6(Hazardous Substances Data)

Usage

General Description

4α-Hydroxyadamantane-1-carboxylic acid is a chemical compound that is a derivative of adamantine, a tricyclic hydrocarbon. It has a hydroxyl group attached to the 4th carbon atom and a carboxylic acid functional group attached to the first carbon atom of the adamantane ring. 4α-Hydroxyadamantane-1-carboxylic acid has potential applications in pharmaceuticals and material sciences due to its unique structure and properties. It can be used as a building block for the synthesis of various pharmaceutical compounds and also as a precursor for the preparation of functionalized materials. Additionally, it may have potential biological activities and could be of interest for further research in the development of new drugs and materials.

Upstream product

• 828-51-3 1-Adamantanecarboxylic acid 
• 56674-87-4 4-oxoadamantane-1-carboxylic acid 
• 81968-76-5 methyl 4-hydroxyadamantane-1-carboxylate 
• 38584-33-7 5-phenyladamantan-2-one 
• 41163-66-0 methyl 4e-hydroxy-1-adamantanecarboxylate 

Downstream Products

• 117821-36-0 1-(1-aminoethyl)-4-adamantanol 
• 81968-76-5 methyl 4-hydroxyadamantane-1-carboxylate 
• 1403353-88-7 C₁₈H₁₅S⁽¹⁺⁾*C₂₅H₃₃F₂O₈S^(1-) 
• 1403353-91-2 C₁₈H₁₅S⁽¹⁺⁾*C₂₅H₃₃F₂O₈S^(1-) 
• 1403353-94-5 C₁₈H₁₅S⁽¹⁺⁾*C₂₄H₃₁F₂O₈S^(1-) 
• 1403353-99-0 C₂₁H₂₁S⁽¹⁺⁾*C₂₄H₃₁F₂O₈S^(1-) 
• 1403354-00-6 C₁₂H₁₅OS⁽¹⁺⁾*C₂₄H₃₁F₂O₈S^(1-) 
• 1403354-01-7 C₁₂H₁₀I⁽¹⁺⁾*C₂₄H₃₁F₂O₈S^(1-) 

Relevant articles and documents

FUSED-RING COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES THEREOF

This disclosure is related to a fused-ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the fused ring compound of formula (I) and/or a pharmaceutically acceptable salt thereof, preparation methods thereof, and use thereof in modulating activity of indoleamine 2, 3-dioxygenase (IDO) and/or tryptophan 2, 3-dioxygenase (TDO). This disclosure further provides methods of treating IDO and/or TDO-associated diseases, including cancer, viral infection and autoimmune diseases.

CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1

This invention relates to novel compounds of the invention pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

Effects of substituent modification on face selection in reduction

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