81983-26-8Relevant articles and documents
Synthesis of 11α-hydroxyprogesterone haptens
Yoshida, Hirokazu,Nakai, Shiro,Nimbari, Fusako,Yoshimoto, Kiyoko,Nishimura, Tadashi
, p. 727 - 738 (1989)
C-4 and C-6 bridged haptens of 11α-hydroxyprogesterone, an anti-androgen, were respectively synthesized via 4,5 and 5α,6α epoxide ring openings using 3-mercaptopropanoic acid.Substitution of 6-bromo derivative of progesterone using the same reagent unexpectedly afforded a C-4 substituted product instead of the normal C-6 substituted product previously reported in the literature.