82-93-9

Basic information

• Product Name: CHLORCYCLIZINE
• Synonyms: 1-((4-chlorophenyl)phenylmethyl)-4-methylpiperazine;1-(4-Chlorobenzhydryl)-4-methylpiperazine;1-(p-chloro-alpha-phenylbenzyl)-4-methyl-piperazin;1-(p-Chloro-alpha-phenylbenzyl)-4-methylpiperazine;1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine;Alergicide;Chlorcycline;Chlorocycline
• CAS NO: 82-93-9
• Molecular Formula: C₁₈H₂₁ClN₂
• Molecular Weight: 300.83
• EINECS: 201-446-0
• Mol File: 82-93-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 25°C
• Boiling Point: bp0.1-0.15 137-145°
• Appearance: /
• Density: 1.0732 (rough estimate)
• Refractive Index: 1.5749 (estimate)
• PKA: pKa 2.43(H2O t = 25 c = 0.002 to 0.01)(Approximate);7.81(H2O t = 25 c = 0.002 to 0.01) (Uncertain)
• Water Solubility: 300.8mg/L(37.5 oC)
• CAS DataBase Reference: CHLORCYCLIZINE(CAS DataBase Reference)
• NIST Chemistry Reference: CHLORCYCLIZINE(82-93-9)
• EPA Substance Registry System: CHLORCYCLIZINE(82-93-9)

Safety Data

• Hazardous Substances Data: 82-93-9(Hazardous Substances Data)

Usage

Brand name

Di-Paralene (Abbott).

Therapeutic Function

Antihistaminic

InChI:InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 64-18-6 formic acid 
• 100-52-7 benzaldehyde 
• 150766-93-1 (4-chlorophenyl)zinc(II) bromide 
• 38111-44-3 phenylzinc(II) bromide 
• 104-88-1 4-chlorobenzaldehyde 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 
• 74-88-4 methyl iodide 
• 134-85-0 4-chlorobenzophenone 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2

We report herein that a borane-trimethylamine complex worked as an efficient reducing agent for the selective methylation and formylation of amines with 1 atm CO2 under metal-free conditions. 6-Amino-2-picoline serves as a highly efficient catalyst for the methylation of various secondary amines, whereas in its absence, the formylation of primary and secondary amines was achieved in high yield with high chemoselectivity. Mechanistic studies suggest that the 6-amino-2-picoline-borane catalytic system operates like an intramolecular frustrated Lewis pair to activate CO2.

Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines

Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes.