82003-39-2 Usage
Description
[3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione, commonly known as (+)-Fumagillin, is a complex organic compound with a fused heterocyclic ring structure. It is a stereoisomer with a 3aR, 5E, 7R, 11aS configuration and is a natural product isolated from the fungus Aspergillus fumigatus. This chemical is recognized for its anti-angiogenic and anti-parasitic properties, making it a promising candidate for therapeutic applications in cancer treatment and as an anti-microbial agent. Its unique structure and biological activity have garnered significant interest in the field of medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Industry:
[3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione is used as a therapeutic agent for its anti-angiogenic properties. [3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione is being studied for its potential in cancer treatment, as it can inhibit the formation of new blood vessels that supply tumors, thereby limiting their growth and spread.
Used in Anti-parasitic Applications:
In the field of anti-parasitic agents, [3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione is used as a treatment option for certain parasitic infections. Its anti-parasitic properties make it a valuable compound in the development of new drugs to combat parasitic diseases.
Used in Medicinal Chemistry Research:
[3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione is used as a subject of interest in medicinal chemistry research. Its unique structure and biological activity provide a foundation for further investigation into its potential applications and the development of new drugs based on its properties.
Used in Drug Development:
In the drug development industry, [3aR,5E,7R,11aS,(+)]-3,3a,4,7,11,11a-Hexahydro-6-methyl-3-methylene-9H-7,10-ethanylylidene-2H-furo[2,3-e]oxecin-2,9-dione is used as a lead compound for the creation of new therapeutic agents. Its anti-angiogenic and anti-parasitic properties make it a valuable starting point for the design and synthesis of novel drugs targeting cancer and parasitic infections.
Check Digit Verification of cas no
The CAS Registry Mumber 82003-39-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,0,0 and 3 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 82003-39:
(7*8)+(6*2)+(5*0)+(4*0)+(3*3)+(2*3)+(1*9)=92
92 % 10 = 2
So 82003-39-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H16O4/c1-8-3-5-11-9(2)14(16)19-13(11)7-10-4-6-12(8)18-15(10)17/h3-4,11-13H,2,5-7H2,1H3/b8-3-
82003-39-2Relevant articles and documents
Bitter Principles of Pertya glabrescens: Two Sesquiterpene Glucosides
Nagumo, Seiji,Nagai, Masahiro,Inoue, Takao
, p. 2302 - 2307 (2007/10/02)
Two bitter principles, glucosyl pertate (I), (α)D -48.6 deg, and glucosyl 3α-hydroxypertate (II), (α)D -10.9 deg, were isolated from the leaves of Pertya glabrescens SCH.BIP. (Compositae).On acid hydrolysis, I and II yielded new sesquiterpene acids, pertic acid (IV), C15H18O4, mp 152-153 deg C (dec.), (α)D -72.7 deg, and 3α-hydroxypertic acid (XI), C15H18O5, mp 250-252 deg C (dec). (α)D +1.6 deg, as their genins,respectively.These genins were chemically correlated with pertilide (VI).The chemical structures of I and II were established as β-D-glucopyranosyl -(7R,8S)-germacra-1(10), 4,11(13)-trien-12,8-olide-14-oate (I) and β-D-glucopyranosyl -(3R,7R,8S)-3-hydroxygermacra-1(10),4,11(13)-trien-12,8-olide-14-oate (II).Keywords - Pertya glabrescens; Compositae; sesquiterpene; germacranolide; sesquiterpene glucoside; sesquiterpene acid; glucosyl pertate; pertic acid; glucosyl 3α-hydroxypertate; 3α-hydroxypertic acid
