82003-90-5

Basic information

• Product Name: Daurichromenic acid
• Synonyms: Daurichromenic acid;(2S)-2-[(3E)-4,8-Dimethyl-3,7-nonadien-1-yl]-5-hydroxy-2,7-dimethyl-2H-1-benzopyran-6-carboxylic acid
• CAS NO: 82003-90-5
• Molecular Formula: C23H30O4
• Molecular Weight: 370.4819
• Mol File: 82003-90-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 503.7±50.0 °C(Predicted)
• Appearance: /
• Density: 1.092±0.06 g/cm3(Predicted)
• PKA: 3.05±0.40(Predicted)
• CAS DataBase Reference: Daurichromenic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Daurichromenic acid(82003-90-5)
• EPA Substance Registry System: Daurichromenic acid(82003-90-5)

Safety Data

• Hazardous Substances Data: 82003-90-5(Hazardous Substances Data)

Usage

Uses

Daurichromenic Acid is a potent anti-HIV agent. Constit. of the leaves of Rhododendron dauricum

Upstream product

• 80557-12-6 Grifolic acid 
• 502-67-0 Farnesal 
• 480-64-8 orsellinic acid 
• 124-38-9 carbon dioxide 
• 1220893-86-6 C₂₂H₂₉BrO₂ 

Relevant articles and documents

Isolation, synthesis and biological activity of grifolic acid dervivatives from the inedible mushroom Albatrellus dispansus

Grifolin, grifolic acid, grifolic acid methyl ester and a new compound grifolinol were isolated from methanolic extract of the inedible mushroom Albatrellus dispansus (Scutigeraceae). Their structures were established by a combination of 2D NMR, MS spectrum and chemical reaction. In addition, (+)- and (-)-daurichromenic acids were obtained by cyclization of grifolic acid. The inhibitory activity of TNF-α, anti HIV and antimicrobial activity of grifolic acid derivatives were examined.{A figure is presented}.

TOTAL SYNTHESIS OF DAURICHROMENIC ACID

The present invention provides a method to prepare 2H-benzo[6]pyrans, such as the anti-HIV natural product daurichromenic acid (1a), by microwave-assisted tandem aldol reaction of a phenolic enolate followed by intramolecular SN2' type cyclization to form the 2H-benzo[6]pyran core structure.