82006-58-4Relevant articles and documents
Fluorinated pentene diamine derivatives
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, (2008/06/13)
Fluorinated alkenylene diamine compounds are inhibitors of ornithine decarboxylase enzyme in vivo and have the following formula: STR1 wherein: Ra represents hydrogen or R2, where R2 is as defined below; Rb represents hydrogen or, when Ra is hydrogen, R2, where R2 is as defined below; Rc represents hydrogen or --COR3, where R3 is as defined below; R1 represents hydrogen or C1 --C6 alkyl; each R2, independently, represents C2 -C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1 -C4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from a carboxy moiety of an L-aminocarboxylic acid; R3 represents hydroxy, or, when Ra and Rb are both hydrogen, C1 -C8 alkoxy, --NR4 R5, where R4 and R5 are as defined below, or an aminocarboxylic acid residue derived by removal of an hydrogen atom from the amino moiety of an L-aminocarboxylic acid; R4 and R5, independently, represent hydrogen or C1 -C4 alkyl; and p represents 1 or 2.
