82019-34-9

Basic information

• Product Name: 2(1H)-Quinoxalinone,1,6,7-trimethyl-(6CI,7CI,9CI)
• Synonyms: 2(1H)-Quinoxalinone,1,6,7-trimethyl-(6CI,7CI,9CI);1,6,7-TRIMETHYLQUINOXALIN-2(1H)-ONE
• CAS NO: 82019-34-9
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.23
• Product Categories: PIPERIDINE
• Mol File: 82019-34-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2(1H)-Quinoxalinone,1,6,7-trimethyl-(6CI,7CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,1,6,7-trimethyl-(6CI,7CI,9CI)(82019-34-9)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,1,6,7-trimethyl-(6CI,7CI,9CI)(82019-34-9)

Safety Data

• Hazardous Substances Data: 82019-34-9(Hazardous Substances Data)

Usage

Structure

A quinoxalinone derivative with three methyl groups attached at positions 1, 6, and 7

Pharmacological activities

Antiproliferative, antibacterial, and antifungal

Potential uses

Antimalarial and antitumor agent

Importance in medicinal chemistry

Unique molecular structure and potential biological activities make it an interesting compound for further research and development.

Upstream product

• 1214-95-5 1,2-dihydro-2-keto-1,6,7-trimethyl-quinoxaline-3-carboxylic acid 
• 28082-82-8 6,7-dimethyl-2-oxo-1,2-dihydroquinoxaline 
• 74-88-4 methyl iodide 
• 3171-45-7 4,5-dimethyl-1,2-phenylenediamine 
• 13641-12-8 4,6,7-trimethyl-3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid carbamoylamide 
• 915944-24-0 methyl 4-fluoro-2-methyl-5-nitrobenzene 
• 105029-06-9 6,7-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one 
• 74-87-3 methylene chloride 
• 28082-82-8 6,7-dimethyl-1H-quinoxalin-2-one 

Downstream Products

• 4951-01-3 4,6,7-trimethyl-3-oxo-N-phenyl-3,4-dihydroquinoxaline-2-carboxamide 

Relevant articles and documents

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.

Visible Light-Promoted Radical Relay Cyclization/C-C Bond Formation of N-Allylbromodifluoroacetamides with Quinoxalin-2(1 H)-ones

A visible light-promoted radical relay of N-allylbromodifluoroacetamide with quinoxalin-2(1H)-ones was developed in which 5-exo-trig cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1H)-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.