820216-46-4

Basic information

• Product Name: 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-
• CAS NO: 820216-46-4
• Molecular Formula: C29H39N3O3S2Si
• Molecular Weight: 569.864
• Mol File: 820216-46-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-(820216-46-4)
• EPA Substance Registry System: 2-Thiophenesulfonamide, N-[3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[[(1R)-2-(1H-indol-3 -yl)-1-methylethyl]amino]ethyl]phenyl]-(820216-46-4)

Safety Data

• Hazardous Substances Data: 820216-46-4(Hazardous Substances Data)

Upstream product

• 2227-64-7 3'-nitro-2-bromoacetophenone 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 776302-69-3 (R)-2-bromo-1-(tert-butyldimethylsilyloxy)-1-(3-nitrophenyl)ethane 
• 820216-60-2 3-[2-bromo-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine 
• 193761-55-6 (R)-2-bromo-1-(3-nitrophenyl)ethan-1-ol 
• 7795-52-0 (-)-alpha-Methyltryptamine 
• 776302-68-2 (R)-N-{3-[2-bromo-1-(tert-butyldimethylsilyloxy)ethyl]phenyl}(2-thiophene)sulfonamide 

Relevant articles and documents

Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β3-adrenergic receptor agonists with high cell permeability

The synthesis and evaluation of a novel series of 1,7-cyclized indole-based human adrenergic receptor (β3-AR) agonists are reported. The synthesis of a variety of 1,7-cyclized indole part was accomplished by the Mitsunobu reaction or a ring closing metathesis (RCM) reaction. SAR studies revealed that expansion of the ring size resulted in considerable selectivity against the β1- and β2-ARs. Compound 26, an eight-membered ring analogue with a double bond on its 1,7-linker portion, was found to be a potent β3-AR agonist (EC50 = 0.75 nM, IA = 90%) with extremely high selectivity for the β3-AR over the β1- and β2-ARs.