820241-20-1Relevant articles and documents
Tetrasubstituted imidazole inhibitors of cytokine release: Probing substituents in the N-1 position
Laufer, Stefan A.,Zimmermann, Werner,Ruff, Kathrin J.
, p. 6311 - 6325 (2007/10/03)
We prepared novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity by using our previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently