82085-87-8

Basic information

• Product Name: 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine
• Synonyms: 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine
• CAS NO: 82085-87-8
• Molecular Weight: 241.29
• Mol File: 82085-87-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine(82085-87-8)
• EPA Substance Registry System: 2-(4'-methoxyphenyl)-1,2-dihydro-4H-3,1-benzoxazine(82085-87-8)

Safety Data

• Hazardous Substances Data: 82085-87-8(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 62460-63-3 2-(4-methoxy-phenyl)-4H-benzo[d][1,3]oxazine 
• 18600-55-0 2-(4-methoxyphenyl)-4H-3,1-benzoxazin-4-one 

Relevant articles and documents

Simple grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives, a rapid synthetic route to 3,1-benzoxazines

The grinding-induced reactions of 2-aminobenzyl alcohol and benzaldehyde derivatives in the presence of 30 mol% of acetic acid to give 3,1-benzoxazines are described. The reactions were performed at room temperature affording 3,1-benzoxazines in yields above 95% and high purity when benzaldehyde and its chloro and nitro derivatives were used.

Synthesis of 3h-quinazolin-4-ones and 4h-3,1-benzoxazin-4-ones via benzylic oxidation and oxidative dehydrogenation using potassium iodide-tert-butyl hydroperoxide

A simple and elegant method for benzylic activation was demonstrated employing the potassium iodide/tert-butyl hydrogen peroxide catalytic system. This methodology was further extended for the synthesis of biologically important heterocycles namely, 3H-quinazolin-4-ones and 4H-3,1-benzoxazin-4-ones including mecloqualone and etaqualone which are important quinazolinone-based drugs used for the treatment of insomnia in good yields.

Synthesis of 3,1-benzoxazines and tetrahydroquinazolines from o-aminobenzyl alcohol and o-aminobenzyl amine - Semi-empirical MO calculations

o-Aminobenzyl alcohol (4) reacts with aldehydes and ketones to the 3,1-benzoxazines 20a/b and 22a/b, whereas the enamine derivatives 24a-c are formed from β-diketones. The isosteric o-amino-benzylamine (1) gives tetrahydroquinazolines 11a/b and 14b as het