82128-59-4

Basic information

• Product Name: 7-Fluoronaphthalene-1-carboxaldehyde
• Synonyms: 7-Fluoronaphthalene-1-carboxaldehyde;7-Fluoro-1-naphthalenecarboxaldehyde;7-fluoronaphthalene-1-carbaldehyde
• CAS NO: 82128-59-4
• Molecular Formula: C11H7FO
• Molecular Weight: 174.1710832
• Product Categories: Aromatics, Miscellaneous Reagents
• Mol File: 82128-59-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 303.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.249±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 7-Fluoronaphthalene-1-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoronaphthalene-1-carboxaldehyde(82128-59-4)
• EPA Substance Registry System: 7-Fluoronaphthalene-1-carboxaldehyde(82128-59-4)

Safety Data

• Hazardous Substances Data: 82128-59-4(Hazardous Substances Data)

Usage

Description

7-Fluoronaphthalene-1-carboxaldehyde is an organic compound that features a naphthalene core with a carboxaldehyde group at the 1-position and a fluorine atom at the 7-position. This unique structure endows it with specific chemical and physical properties, making it a valuable intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
7-Fluoronaphthalene-1-carboxaldehyde is used as a key reagent in the synthesis of oxazolidine-2,4-diones. These compounds exhibit hypoglycemic activity, which is beneficial for the development of new drugs to treat diabetes and related metabolic disorders. The presence of the fluorine atom at the 7-position and the carboxaldehyde group at the 1-position in 7-fluoronaphthalene-1-carboxaldehyde allows for the formation of these bioactive oxazolidine-2,4-diones through specific chemical reactions, potentially leading to improved therapeutic options for patients with diabetes.

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 323-09-1 2-fluoronaphthalene 
• 1248672-93-6 C₁₁H₁₁FO 

Relevant articles and documents

Synthesizing method of fused-ring aryl substituted formaldehyde compound

The invention discloses a synthesizing method of a fused-ring aryl substituted formaldehyde compound, and belongs to the technical field of synthesis technologies of aldehyde compounds. According to the technical scheme, the synthesizing method of the fused-ring aryl substituted formaldehyde compound particularly comprises the steps that a 1-phenyl-4-pentyne-2-alcohol compound or a 1-(naphthalene-1-base)-4-pentyne-2-alcohol compound is dissolved in solvent, accelerant is added, a reaction is conducted in an air atmosphere at 0-40 DEG C, and the fused-ring aryl substituted formaldehyde compound is obtained, wherein the solvent adopts tetrahydrofuran or acetonitrile or dichloromethane, and the accelerant adopts iodine monochloride. The synthesizing method starts from the raw materials which are simple and easy to prepared, and by means of a one-pot cascade reaction, a 1-naphthaldehyde compound or a 1-phenanthrenecarboxaldehyde compound is obtained directly, that is to say, fused-ring aryl and aldehyde groups are built simultaneously in the one-pot cascade reaction; operation is convenient, the condition is mild, atoms are high in economic efficiency, substrates are wide in application scope, and the synthesizing method of the fused-ring aryl substituted formaldehyde compound is suitable for industrial production.

Hypoglycemic 5-substituted oxazolidine-2,4-diones

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.